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1918 H1N1 Viral influenza polymerase heterotrimer with Nb8196 core

Electron Microscopy
4.48Å resolution
PDB entry 7nj3 coloured by chain, front view.
PDB entry 7nj3 coloured by chain, side view.
PDB entry 7nj3 coloured by chain, top view.
Source organisms:
Assembly composition:
hetero hexamer (preferred)
Entry contents: 4 distinct polypeptide molecules
2 distinct RNA molecules

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Assemblies

Assembly 1 (preferred)
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Multimeric state: hetero hexamer
Accessible surface area: 70902.03 Å2
Buried surface area: 38749.41 Å2
Dissociation area: 88.67 Å2
Dissociation energy (ΔGdiss): -11.44 kcal/mol
Dissociation entropy (TΔSdiss): 11.8 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-212231

Macromolecules

Polymerase acidic protein
Chain: A
Length: 716 amino acids
Theoretical weight: 82.71 KDa
Source organism: Influenza A virus (A/Brevig Mission/1/1918(H1N1))
Expression system: Spodoptera frugiperda
Polymerase acidic protein in PDB entry 7nj3, assembly 1, front view.
Polymerase acidic protein in PDB entry 7nj3, assembly 1, side view.
Polymerase acidic protein in PDB entry 7nj3, assembly 1, top view.
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RNA-directed RNA polymerase catalytic subunit
Chain: B
Length: 757 amino acids
Theoretical weight: 86.63 KDa
Source organism: Influenza A virus (A/Brevig Mission/1/1918(H1N1))
Expression system: Spodoptera frugiperda
RNA-directed RNA polymerase catalytic subunit in PDB entry 7nj3, assembly 1, front view.
RNA-directed RNA polymerase catalytic subunit in PDB entry 7nj3, assembly 1, side view.
RNA-directed RNA polymerase catalytic subunit in PDB entry 7nj3, assembly 1, top view.
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Polymerase basic protein 2,Immunoglobulin G-binding protein A
Chain: C
Length: 905 amino acids
Theoretical weight: 102.38 KDa
Source organism: Staphylococcus aureus
Expression system: Spodoptera frugiperda
Polymerase basic protein 2,Immunoglobulin G-binding protein A in PDB entry 7nj3, assembly 1, front view.
Polymerase basic protein 2,Immunoglobulin G-binding protein A in PDB entry 7nj3, assembly 1, side view.
Polymerase basic protein 2,Immunoglobulin G-binding protein A in PDB entry 7nj3, assembly 1, top view.
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Nanobody8196 core
Chain: F
Length: 132 amino acids
Theoretical weight: 14.51 KDa
Source organism: Camelidae mixed library
Expression system: Escherichia coli
Nanobody8196 core in PDB entry 7nj3, assembly 1, front view.
Nanobody8196 core in PDB entry 7nj3, assembly 1, side view.
Nanobody8196 core in PDB entry 7nj3, assembly 1, top view.
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RNA chain E
Name: RNA (5'-R(P*GP*GP*CP*CP*UP*GP*CP*U)-3')
Representative chains: E
Source organism: Influenza A virus (A/Brevig Mission/1/1918(H1N1)) [88776]
Expression system: Not provided
Length: 17 nucleotides
Theoretical weight: 5.34 KDa
RNA (5'-R(P*GP*GP*CP*CP*UP*GP*CP*U)-3') in PDB entry 7nj3, assembly 1, front view.
RNA (5'-R(P*GP*GP*CP*CP*UP*GP*CP*U)-3') in PDB entry 7nj3, assembly 1, side view.
RNA (5'-R(P*GP*GP*CP*CP*UP*GP*CP*U)-3') in PDB entry 7nj3, assembly 1, top view.
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RNA chain D
Name: RNA (5'-R(P*AP*GP*UP*AP*GP*AP*AP*AP*CP*AP*AP*GP*GP*CP*C)-3')
Representative chains: D
Source organism: Influenza A virus (A/Brevig Mission/1/1918(H1N1)) [88776]
Expression system: Not provided
Length: 15 nucleotides
Theoretical weight: 4.86 KDa
RNA (5'-R(P*AP*GP*UP*AP*GP*AP*AP*AP*CP*AP*AP*GP*GP*CP*C)-3') in PDB entry 7nj3, assembly 1, front view.
RNA (5'-R(P*AP*GP*UP*AP*GP*AP*AP*AP*CP*AP*AP*GP*GP*CP*C)-3') in PDB entry 7nj3, assembly 1, side view.
RNA (5'-R(P*AP*GP*UP*AP*GP*AP*AP*AP*CP*AP*AP*GP*GP*CP*C)-3') in PDB entry 7nj3, assembly 1, top view.
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