› 7np3

Electron Microscopy
3.3Å resolution

cAMP-free rabbit HCN4 stabilized in LMNG-CHS detergent mixture

Released:
DOI: 10.2210/pdb7np3/pdb
PDB entry 7np3 coloured by chain, front view.
PDB entry 7np3 coloured by chain, side view.
PDB entry 7np3 coloured by chain, top view.
Source organism: Oryctolagus cuniculus
Primary publication:
Gating movements and ion permeation in HCN4 pacemaker channels.
Saponaro A, Bauer D, Giese MH, Swuec P, Porro A, Gasparri F, Sharifzadeh AS, Chaves-Sanjuan A, Alberio L, Parisi G, Cerutti G, Clarke OB, Hamacher K, Colecraft HM, Mancia F, Hendrickson WA, Siegelbaum SA, DiFrancesco D, Bolognesi M, Thiel G, Santoro B, Moroni A
Mol Cell 81 2929-2943.e6 (2021)
PMID: 34166608
Related structures: EMD-12512

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-193583 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 892 amino acids
Theoretical weight: 98.52 KDa
Source organism: Oryctolagus cuniculus
Expression system: Homo sapiens
UniProt:
  • Canonical: Q9TV66 (Residues: 1-1103, 1104-1175; Coverage: 76%)
Gene names: HAC4, HCN4
Sequence domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.3Å
Relevant EMDB volumes: EMD-12512
Expression system: Homo sapiens

Quick links

Citations

7 review citations

Membranes under the Magnetic Lens: A Dive into the Diverse World of Membrane Protein Structures Using Cryo-EM.
Piper et al. (2022)
6 more

8 mentions without citation

Gating movements and ion permeation in HCN4 pacemaker channels.
Saponaro et al. (2021)
7 more