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cAMP-free rabbit HCN4 stabilized in LMNG-CHS detergent mixture

Electron Microscopy
3.3Å resolution
PDB entry 7np3 coloured by chain, front view.
PDB entry 7np3 coloured by chain, side view.
PDB entry 7np3 coloured by chain, top view.
Source organism: Oryctolagus cuniculus
Assembly composition:
homo tetramer (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4
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Multimeric state: homo tetramer
Accessible surface area: 94402.58 Å2
Buried surface area: 21201.41 Å2
Dissociation area: 10,600.71 Å2
Dissociation energy (ΔGdiss): 121 kcal/mol
Dissociation entropy (TΔSdiss): 49.29 kcal/mol
Symmetry number: 4
PDBe Complex ID: PDB-CPX-193583

Macromolecules

Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4
Chains: A, B, C, D
Length: 892 amino acids
Theoretical weight: 98.52 KDa
Source organism: Oryctolagus cuniculus
Expression system: Homo sapiens
UniProt:
  • Canonical: Q9TV66 (Residues: 1-1103, 1104-1175; Coverage: 76%)
Gene names: HAC4, HCN4
Pfam:
InterPro:
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 in PDB entry 7np3, assembly 1, front view.
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 in PDB entry 7np3, assembly 1, side view.
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 in PDB entry 7np3, assembly 1, top view.
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