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CRYSTAL STRUCTURE OF HUMAN CYTOSOLIC BRANCHED-CHAIN AMINOTRANSFERASE (BCAT1) IN COMPLEX WITH PLP AND INHIBITOR COMPOUND 12

X-ray diffraction
2.15Å resolution
PDB entry 7nwm coloured by chain, front view.
PDB entry 7nwm coloured by chain, side view.
PDB entry 7nwm coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
homo dimer (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Branched-chain-amino-acid aminotransferase, cytosolic
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Multimeric state: homo dimer
Accessible surface area: 26839.61 Å2
Buried surface area: 6046.31 Å2
Dissociation area: 2,482.89 Å2
Dissociation energy (ΔGdiss): 31.36 kcal/mol
Dissociation entropy (TΔSdiss): 14.39 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-157075

Macromolecules

Branched-chain-amino-acid aminotransferase, cytosolic
Chains: A, B
Length: 389 amino acids
Theoretical weight: 43.29 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P54687 (Residues: 1-386; Coverage: 100%)
Gene names: BCAT1, BCT1, ECA39
Pfam: Amino-transferase class IV
InterPro:
Branched-chain-amino-acid aminotransferase, cytosolic in PDB entry 7nwm, assembly 1, front view.
Branched-chain-amino-acid aminotransferase, cytosolic in PDB entry 7nwm, assembly 1, side view.
Branched-chain-amino-acid aminotransferase, cytosolic in PDB entry 7nwm, assembly 1, top view.
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