› 7nxf

Electron Microscopy
3.1Å resolution

Structure of the fungal plasma membrane proton pump Pma1 in its auto-inhibited state - monomer unit

Released:
DOI: 10.2210/pdb7nxf/pdb
PDB entry 7nxf coloured by chain, front view.
PDB entry 7nxf coloured by chain, side view.
PDB entry 7nxf coloured by chain, top view.
Source organism: Neurospora crassa
Primary publication:
Structure of the hexameric fungal plasma membrane proton pump in its autoinhibited state.
Heit S, Geurts MMG, Murphy BJ, Corey RA, Mills DJ, Kühlbrandt W, Bublitz M
Sci Adv 7 eabj5255 (2021)
PMID: 34757782
Related structures: EMD-12638

Function and Biology Details

Reaction catalysed: 
ATP + H(2)O + H(+)(Side 1) = ADP + phosphate + H(+)(Side 2)
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-139355 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Plasma membrane ATPase Chain: A
Molecule details ›
Chain: A
Length: 920 amino acids
Theoretical weight: 99.98 KDa
Source organism: Neurospora crassa
UniProt:
  • Canonical: P07038 (Residues: 1-920; Coverage: 100%)
Gene names: B1D1.210, NCU01680, pma-1
Sequence domains:

Ligands and Environments

3 bound ligands:
Ligand ADP 1 x ADP
Ligand MG 1 x MG
Ligand K 1 x K
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.1Å
Relevant EMDB volumes: EMD-12638

Quick links

Citations

3 review citations

P-type ATPases: Many more enigmas left to solve.
Palmgren M. (2023)
2 more

1 mention without citation

Structure of the hexameric fungal plasma membrane proton pump in its autoinhibited state.
Heit et al. (2021)