7o2w

Electron Microscopy

Structure of the C9orf72-SMCR8 complex

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
PDBe Complex ID:
PDB-CPX-142586 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Guanine nucleotide exchange factor C9orf72; Ubiquitin-like protein SMT3 Chain: A
Molecule details ›
Chain: A
Length: 593 amino acids
Theoretical weight: 67.17 KDa
Source organisms: Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q12306 (Residues: 2-96; Coverage: 94%)
  • Canonical: Q96LT7 (Residues: 1-481; Coverage: 100%)
Gene names: C9orf72, D9719.15, DENND9, DENNL72, SMT3, YDR510W
Sequence domains:
Guanine nucleotide exchange protein SMCR8; Maltose/maltodextrin-binding periplasmic protein Chain: B
Molecule details ›
Chain: B
Length: 1206 amino acids
Theoretical weight: 134.39 KDa
Source organisms: Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q8TEV9 (Residues: 1-439, 620-937; Coverage: 81%)
  • Canonical: P0AEX9 (Residues: 27-392; Coverage: 99%)
Gene names: JW3994, SMCR8, b4034, malE
Sequence domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Relevant EMDB volumes: EMD-12700
Expression system: Spodoptera frugiperda