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Structure of the C9orf72-SMCR8 complex

Electron Microscopy
PDB entry 7o2w coloured by chain, front view.
PDB entry 7o2w coloured by chain, side view.
PDB entry 7o2w coloured by chain, top view.
Source organisms:
Assembly composition:
hetero dimer (preferred)
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Guanine nucleotide exchange factor C9orf72, Ubiquitin-like protein SMT3 and Guanine nucleotide exchange protein SMCR8, Maltose/maltodextrin-binding pe...
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Multimeric state: hetero dimer
Accessible surface area: 42114.12 Å2
Buried surface area: 4625.86 Å2
Dissociation area: 2,312.93 Å2
Dissociation energy (ΔGdiss): 25.9 kcal/mol
Dissociation entropy (TΔSdiss): 14.63 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-142586

Macromolecules

Guanine nucleotide exchange factor C9orf72; Ubiquitin-like protein SMT3
Chain: A
Length: 593 amino acids
Theoretical weight: 67.17 KDa
Source organisms: Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q12306 (Residues: 2-96; Coverage: 94%)
  • Canonical: Q96LT7 (Residues: 1-481; Coverage: 100%)
    • nullnull
Gene names: C9orf72, D9719.15, DENND9, DENNL72, SMT3, YDR510W
Pfam:
InterPro:
Guanine nucleotide exchange factor C9orf72 in PDB entry 7o2w, assembly 1, front view.
Guanine nucleotide exchange factor C9orf72 in PDB entry 7o2w, assembly 1, side view.
Guanine nucleotide exchange factor C9orf72 in PDB entry 7o2w, assembly 1, top view.
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Guanine nucleotide exchange protein SMCR8; Maltose/maltodextrin-binding periplasmic protein
Chain: B
Length: 1206 amino acids
Theoretical weight: 134.39 KDa
Source organisms: Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q8TEV9 (Residues: 1-439, 620-937; Coverage: 81%)
  • Canonical: P0AEX9 (Residues: 27-392; Coverage: 99%)
    • nullnull
Gene names: JW3994, SMCR8, b4034, malE
Pfam:
InterPro:
Guanine nucleotide exchange protein SMCR8 in PDB entry 7o2w, assembly 1, front view.
Guanine nucleotide exchange protein SMCR8 in PDB entry 7o2w, assembly 1, side view.
Guanine nucleotide exchange protein SMCR8 in PDB entry 7o2w, assembly 1, top view.
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