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Murine supercomplex CIII2CIV in the intermediate locked conformation

Electron Microscopy
3.6Å resolution
PDB entry 7o3e coloured by chain, front view.
PDB entry 7o3e coloured by chain, side view.
PDB entry 7o3e coloured by chain, top view.
Source organism: Mus musculus
Assembly composition:
hetero 31-mer (preferred)
Entry contents: 23 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Multimeric state: hetero 31-mer
Accessible surface area: 207589.16 Å2
Buried surface area: 153448.85 Å2
Dissociation area: 1,195.42 Å2
Dissociation energy (ΔGdiss): 8.02 kcal/mol
Dissociation entropy (TΔSdiss): 8.85 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-132298

Macromolecules

Cytochrome b-c1 complex subunit 1, mitochondrial
Chains: A, L
Length: 446 amino acids
Theoretical weight: 49.36 KDa
Source organism: Mus musculus
UniProt:
  • Canonical: Q9CZ13 (Residues: 35-480; Coverage: 93%)
Gene name: Uqcrc1
Pfam:
InterPro:
Cytochrome b-c1 complex subunit 1, mitochondrial in PDB entry 7o3e, assembly 1, front view.
Cytochrome b-c1 complex subunit 1, mitochondrial in PDB entry 7o3e, assembly 1, side view.
Cytochrome b-c1 complex subunit 1, mitochondrial in PDB entry 7o3e, assembly 1, top view.
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Cytochrome b-c1 complex subunit 2, mitochondrial
Chains: B, M
Length: 439 amino acids
Theoretical weight: 46.64 KDa
Source organism: Mus musculus
UniProt:
  • Canonical: Q9DB77 (Residues: 15-453; Coverage: 97%)
Gene name: Uqcrc2
Pfam:
InterPro:
Cytochrome b-c1 complex subunit 2, mitochondrial in PDB entry 7o3e, assembly 1, front view.
Cytochrome b-c1 complex subunit 2, mitochondrial in PDB entry 7o3e, assembly 1, side view.
Cytochrome b-c1 complex subunit 2, mitochondrial in PDB entry 7o3e, assembly 1, top view.
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Cytochrome b
Chains: C, N
Length: 381 amino acids
Theoretical weight: 43.24 KDa
Source organism: Mus musculus
UniProt:
  • Canonical: P00158 (Residues: 1-381; Coverage: 100%)
Gene names: Cob, Cytb, Mt-Cyb, Mtcyb, mt-Cytb
Pfam:
InterPro:
Cytochrome b in PDB entry 7o3e, assembly 1, front view.
Cytochrome b in PDB entry 7o3e, assembly 1, side view.
Cytochrome b in PDB entry 7o3e, assembly 1, top view.
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Cytochrome c1, heme protein, mitochondrial
Chains: D, O
Length: 241 amino acids
Theoretical weight: 27.31 KDa
Source organism: Mus musculus
UniProt:
  • Canonical: Q9D0M3 (Residues: 85-325; Coverage: 74%)
Gene name: Cyc1
Pfam: Cytochrome C1 family
InterPro:
Cytochrome c1, heme protein, mitochondrial in PDB entry 7o3e, assembly 1, front view.
Cytochrome c1, heme protein, mitochondrial in PDB entry 7o3e, assembly 1, side view.
Cytochrome c1, heme protein, mitochondrial in PDB entry 7o3e, assembly 1, top view.
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Cytochrome b-c1 complex subunit 7
Chains: F, Q
Length: 110 amino acids
Theoretical weight: 13.46 KDa
Source organism: Mus musculus
UniProt:
  • Canonical: Q9D855 (Residues: 2-111; Coverage: 99%)
Gene name: Uqcrb
Pfam: Ubiquinol-cytochrome C reductase complex 14kD subunit
InterPro:
Cytochrome b-c1 complex subunit 7 in PDB entry 7o3e, assembly 1, front view.
Cytochrome b-c1 complex subunit 7 in PDB entry 7o3e, assembly 1, side view.
Cytochrome b-c1 complex subunit 7 in PDB entry 7o3e, assembly 1, top view.
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Cytochrome b-c1 complex subunit 8
Chains: G, R
Length: 81 amino acids
Theoretical weight: 9.65 KDa
Source organism: Mus musculus
UniProt:
  • Canonical: Q9CQ69 (Residues: 2-82; Coverage: 99%)
Gene name: Uqcrq
Pfam: UcrQ family
InterPro:
Cytochrome b-c1 complex subunit 8 in PDB entry 7o3e, assembly 1, front view.
Cytochrome b-c1 complex subunit 8 in PDB entry 7o3e, assembly 1, side view.
Cytochrome b-c1 complex subunit 8 in PDB entry 7o3e, assembly 1, top view.
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Cytochrome b-c1 complex subunit 6, mitochondrial
Chains: H, S
Length: 76 amino acids
Theoretical weight: 9 KDa
Source organism: Mus musculus
UniProt:
  • Canonical: P99028 (Residues: 14-89; Coverage: 85%)
Gene name: Uqcrh
Pfam: Ubiquinol-cytochrome C reductase hinge protein
InterPro:
Cytochrome b-c1 complex subunit 6, mitochondrial in PDB entry 7o3e, assembly 1, front view.
Cytochrome b-c1 complex subunit 6, mitochondrial in PDB entry 7o3e, assembly 1, side view.
Cytochrome b-c1 complex subunit 6, mitochondrial in PDB entry 7o3e, assembly 1, top view.
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Cytochrome b-c1 complex subunit Rieske, mitochondrial
Chain: P
Length: 196 amino acids
Theoretical weight: 21.52 KDa
Source organism: Mus musculus
UniProt:
  • Canonical: Q9CR68 (Residues: 79-274; Coverage: 72%)
Gene name: Uqcrfs1
Pfam:
InterPro:
Cytochrome b-c1 complex subunit Rieske, mitochondrial in PDB entry 7o3e, assembly 1, front view.
Cytochrome b-c1 complex subunit Rieske, mitochondrial in PDB entry 7o3e, assembly 1, side view.
Cytochrome b-c1 complex subunit Rieske, mitochondrial in PDB entry 7o3e, assembly 1, top view.
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Cytochrome b-c1 complex subunit 9
Chain: T
Length: 78 amino acids
Theoretical weight: 7.9 KDa
Source organism: Mus musculus
UniProt:
  • Canonical: Q9CR68 (Residues: 1-78; Coverage: 29%)
Gene name: Uqcrfs1
Pfam: Ubiquinol-cytochrome c reductase 8 kDa, N-terminal
InterPro:
Cytochrome b-c1 complex subunit 9 in PDB entry 7o3e, assembly 1, front view.
Cytochrome b-c1 complex subunit 9 in PDB entry 7o3e, assembly 1, side view.
Cytochrome b-c1 complex subunit 9 in PDB entry 7o3e, assembly 1, top view.
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Cox7a2l protein
Chain: I
Length: 113 amino acids
Theoretical weight: 12.58 KDa
Source organism: Mus musculus
UniProt:
  • Canonical: Q99KD6 (Residues: 1-113; Coverage: 100%)
Gene names: Cox7a2l, Gm6969
Pfam: Cytochrome c oxidase subunit VII
InterPro:
Cox7a2l protein in PDB entry 7o3e, assembly 1, front view.
Cox7a2l protein in PDB entry 7o3e, assembly 1, side view.
Cox7a2l protein in PDB entry 7o3e, assembly 1, top view.
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Cytochrome c oxidase subunit 1
Chain: a
Length: 514 amino acids
Theoretical weight: 56.95 KDa
Source organism: Mus musculus
UniProt:
  • Canonical: P00397 (Residues: 1-514; Coverage: 100%)
Gene names: COI, Mtco1, mt-Co1
Pfam: Cytochrome C and Quinol oxidase polypeptide I
InterPro:
Cytochrome c oxidase subunit 1 in PDB entry 7o3e, assembly 1, front view.
Cytochrome c oxidase subunit 1 in PDB entry 7o3e, assembly 1, side view.
Cytochrome c oxidase subunit 1 in PDB entry 7o3e, assembly 1, top view.
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Cytochrome c oxidase subunit 2
Chain: b
Length: 227 amino acids
Theoretical weight: 25.99 KDa
Source organism: Mus musculus
UniProt:
  • Canonical: P00405 (Residues: 1-227; Coverage: 100%)
Gene names: COII, COX2, Mtco2, mt-Co2
Pfam:
InterPro:
Cytochrome c oxidase subunit 2 in PDB entry 7o3e, assembly 1, front view.
Cytochrome c oxidase subunit 2 in PDB entry 7o3e, assembly 1, side view.
Cytochrome c oxidase subunit 2 in PDB entry 7o3e, assembly 1, top view.
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Cytochrome c oxidase subunit 3
Chain: c
Length: 261 amino acids
Theoretical weight: 29.95 KDa
Source organism: Mus musculus
UniProt:
  • Canonical: P00416 (Residues: 1-261; Coverage: 100%)
Gene names: COIII, Mtco3, mt-Co3
Pfam: Cytochrome c oxidase subunit III
InterPro:
Cytochrome c oxidase subunit 3 in PDB entry 7o3e, assembly 1, front view.
Cytochrome c oxidase subunit 3 in PDB entry 7o3e, assembly 1, side view.
Cytochrome c oxidase subunit 3 in PDB entry 7o3e, assembly 1, top view.
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Cytochrome c oxidase subunit 4 isoform 1, mitochondrial
Chain: d
Length: 147 amino acids
Theoretical weight: 17.23 KDa
Source organism: Mus musculus
UniProt:
  • Canonical: P19783 (Residues: 23-169; Coverage: 87%)
Gene names: Cox4, Cox4a, Cox4i1, Coxiv
Pfam: Cytochrome c oxidase subunit IV
InterPro:
Cytochrome c oxidase subunit 4 isoform 1, mitochondrial in PDB entry 7o3e, assembly 1, front view.
Cytochrome c oxidase subunit 4 isoform 1, mitochondrial in PDB entry 7o3e, assembly 1, side view.
Cytochrome c oxidase subunit 4 isoform 1, mitochondrial in PDB entry 7o3e, assembly 1, top view.
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Cytochrome c oxidase subunit 5A, mitochondrial
Chain: e
Length: 109 amino acids
Theoretical weight: 12.45 KDa
Source organism: Mus musculus
UniProt:
  • Canonical: P12787 (Residues: 38-146; Coverage: 75%)
Gene name: Cox5a
Pfam: Cytochrome c oxidase subunit Va
InterPro:
Cytochrome c oxidase subunit 5A, mitochondrial in PDB entry 7o3e, assembly 1, front view.
Cytochrome c oxidase subunit 5A, mitochondrial in PDB entry 7o3e, assembly 1, side view.
Cytochrome c oxidase subunit 5A, mitochondrial in PDB entry 7o3e, assembly 1, top view.
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Cytochrome c oxidase subunit 5B, mitochondrial
Chain: f
Length: 99 amino acids
Theoretical weight: 10.86 KDa
Source organism: Mus musculus
UniProt:
  • Canonical: P19536 (Residues: 30-128; Coverage: 77%)
Gene name: Cox5b
Pfam: Cytochrome c oxidase subunit Vb
InterPro:
Cytochrome c oxidase subunit 5B, mitochondrial in PDB entry 7o3e, assembly 1, front view.
Cytochrome c oxidase subunit 5B, mitochondrial in PDB entry 7o3e, assembly 1, side view.
Cytochrome c oxidase subunit 5B, mitochondrial in PDB entry 7o3e, assembly 1, top view.
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Cytochrome c oxidase subunit 6A2, mitochondrial
Chain: g
Length: 85 amino acids
Theoretical weight: 9.44 KDa
Source organism: Mus musculus
UniProt:
  • Canonical: P43023 (Residues: 13-97; Coverage: 88%)
Gene name: Cox6a2
Pfam: Cytochrome c oxidase subunit VIa
InterPro:
Cytochrome c oxidase subunit 6A2, mitochondrial in PDB entry 7o3e, assembly 1, front view.
Cytochrome c oxidase subunit 6A2, mitochondrial in PDB entry 7o3e, assembly 1, side view.
Cytochrome c oxidase subunit 6A2, mitochondrial in PDB entry 7o3e, assembly 1, top view.
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Cytochrome c oxidase subunit 6B1
Chain: h
Length: 85 amino acids
Theoretical weight: 9.96 KDa
Source organism: Mus musculus
UniProt:
  • Canonical: P56391 (Residues: 2-86; Coverage: 99%)
Gene names: Cox6b, Cox6b1
Pfam: Cytochrome oxidase c subunit VIb
InterPro:
Cytochrome c oxidase subunit 6B1 in PDB entry 7o3e, assembly 1, front view.
Cytochrome c oxidase subunit 6B1 in PDB entry 7o3e, assembly 1, side view.
Cytochrome c oxidase subunit 6B1 in PDB entry 7o3e, assembly 1, top view.
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Cytochrome c oxidase subunit 6C
Chain: i
Length: 75 amino acids
Theoretical weight: 8.35 KDa
Source organism: Mus musculus
UniProt:
  • Canonical: Q9CPQ1 (Residues: 2-76; Coverage: 99%)
Gene name: Cox6c
Pfam: Cytochrome c oxidase subunit VIc
InterPro:
Cytochrome c oxidase subunit 6C in PDB entry 7o3e, assembly 1, front view.
Cytochrome c oxidase subunit 6C in PDB entry 7o3e, assembly 1, side view.
Cytochrome c oxidase subunit 6C in PDB entry 7o3e, assembly 1, top view.
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Cytochrome c oxidase subunit 7B, mitochondrial
Chain: k
Length: 56 amino acids
Theoretical weight: 6.32 KDa
Source organism: Mus musculus
UniProt:
  • Canonical: P56393 (Residues: 25-80; Coverage: 70%)
Gene name: Cox7b
Pfam: Cytochrome C oxidase chain VIIB
InterPro:
Cytochrome c oxidase subunit 7B, mitochondrial in PDB entry 7o3e, assembly 1, front view.
Cytochrome c oxidase subunit 7B, mitochondrial in PDB entry 7o3e, assembly 1, side view.
Cytochrome c oxidase subunit 7B, mitochondrial in PDB entry 7o3e, assembly 1, top view.
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Cytochrome c oxidase subunit 7C, mitochondrial
Chain: l
Length: 47 amino acids
Theoretical weight: 5.45 KDa
Source organism: Mus musculus
UniProt:
  • Canonical: P17665 (Residues: 17-63; Coverage: 75%)
Gene names: Cox7c, Cox7c1
Pfam: Cytochrome c oxidase subunit VIIc
InterPro:
Cytochrome c oxidase subunit 7C, mitochondrial in PDB entry 7o3e, assembly 1, front view.
Cytochrome c oxidase subunit 7C, mitochondrial in PDB entry 7o3e, assembly 1, side view.
Cytochrome c oxidase subunit 7C, mitochondrial in PDB entry 7o3e, assembly 1, top view.
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Cytochrome c oxidase subunit 8B, mitochondrial
Chain: m
Length: 46 amino acids
Theoretical weight: 4.66 KDa
Source organism: Mus musculus
UniProt:
  • Canonical: P48772 (Residues: 25-70; Coverage: 66%)
Gene names: Cox8b, Cox8h
Pfam: Cytochrome oxidase c subunit VIII
InterPro:
Cytochrome c oxidase subunit 8B, mitochondrial in PDB entry 7o3e, assembly 1, front view.
Cytochrome c oxidase subunit 8B, mitochondrial in PDB entry 7o3e, assembly 1, side view.
Cytochrome c oxidase subunit 8B, mitochondrial in PDB entry 7o3e, assembly 1, top view.
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Cytochrome b-c1 complex subunit 9
Chains: J, U
Length: 63 amino acids
Theoretical weight: 7.33 KDa
Source organism: Mus musculus
UniProt:
  • Canonical: Q8R1I1 (Residues: 2-64; Coverage: 98%)
Gene name: Uqcr10
Pfam: Ubiquinol-cytochrome C reductase, UQCRX/QCR9 like
InterPro:
Cytochrome b-c1 complex subunit 9 in PDB entry 7o3e, assembly 1, front view.
Cytochrome b-c1 complex subunit 9 in PDB entry 7o3e, assembly 1, side view.
Cytochrome b-c1 complex subunit 9 in PDB entry 7o3e, assembly 1, top view.
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