Assemblies
Assembly Name:
DNA-directed RNA polymerase I complex and DNA
Multimeric state:
hetero pentadecamer
Accessible surface area:
162344.31 Å2
Buried surface area:
77410.37 Å2
Dissociation area:
720.49
Å2
Dissociation energy (ΔGdiss):
1.87
kcal/mol
Dissociation entropy (TΔSdiss):
10.77
kcal/mol
Symmetry number:
1
PDBe Complex ID:
PDB-CPX-121722
Macromolecules
Chain: A
Length: 1720 amino acids
Theoretical weight: 195.07 KDa
Source organism: Homo sapiens
UniProt:
Pfam:
Length: 1720 amino acids
Theoretical weight: 195.07 KDa
Source organism: Homo sapiens
UniProt:
- Canonical:
O95602 (Residues: 1-1720; Coverage: 100%)
Pfam:
- RNA polymerase Rpb1, domain 1
- RNA polymerase Rpb1, domain 2
- RNA polymerase Rpb1, domain 3
- RNA polymerase Rpb1, domain 4
- RNA polymerase Rpb1, domain 5
- RNA polymerase Rpb1, clamp domain superfamily
- RNA polymerase Rpb1, domain 1
- DNA-directed RNA pol I, largest subunit, N-terminal domain
- DNA-directed RNA polymerase, subunit beta-prime
- RNA polymerase, N-terminal
- RNA polymerase, alpha subunit
- RNA polymerase Rpb1, domain 3
- RNA polymerase Rpb1, domain 3 superfamily
- RNA polymerase Rpb1, funnel domain superfamily
- RNA polymerase Rpb1, domain 4
- RNA polymerase Rpb1, domain 5
- DNA-directed RNA pol I, largest subunit, C-terminal domain
Chain: B
Length: 1135 amino acids
Theoretical weight: 128.38 KDa
Source organism: Homo sapiens
UniProt:
Pfam:
Length: 1135 amino acids
Theoretical weight: 128.38 KDa
Source organism: Homo sapiens
UniProt:
- Canonical:
Q9H9Y6 (Residues: 1-1135; Coverage: 100%)
Pfam:
- RNA polymerase beta subunit
- RNA polymerase Rpb2, domain 2
- RNA polymerase Rpb2, domain 3
- RNA polymerase I, Rpa2 specific domain
- RNA polymerase Rpb2, domain 6
- RNA polymerase Rpb2, domain 7
- DNA-directed RNA polymerase, subunit 2
- RNA polymerase, beta subunit, protrusion
- RNA polymerase Rpb2, domain 2
- RNA polymerase Rpb2, domain 2 superfamily
- RNA polymerase Rpb2, domain 3
- DNA-directed RNA polymerase I subunit RPA2, domain 4
- DNA-directed RNA polymerase, subunit 2, hybrid-binding domain
- DNA-directed RNA polymerase, subunit 2, hybrid-binding domain superfamily
- RNA polymerase Rpb2, OB-fold
- RNA polymerase, beta subunit, conserved site
- RNA polymerase Rpb2, domain 7
Chain: C
Length: 346 amino acids
Theoretical weight: 39.3 KDa
Source organism: Homo sapiens
UniProt:
Pfam:
InterPro:
Length: 346 amino acids
Theoretical weight: 39.3 KDa
Source organism: Homo sapiens
UniProt:
- Canonical:
O15160 (Residues: 1-346; Coverage: 100%)
Pfam:
InterPro:
- RNA polymerase, RBP11-like subunit
- DNA-directed RNA polymerases I and III subunit AC40
- DNA-directed RNA polymerase subunit Rpo3/Rpb3/RPAC1
- DNA-directed RNA polymerase, RpoA/D/Rpb3-type
- DNA-directed RNA polymerase, 30-40kDa subunit, conserved site
- DNA-directed RNA polymerase, insert domain superfamily
- DNA-directed RNA polymerase, insert domain
Chain: E
Length: 210 amino acids
Theoretical weight: 24.64 KDa
Source organism: Homo sapiens
UniProt:
Pfam:
InterPro:
Length: 210 amino acids
Theoretical weight: 24.64 KDa
Source organism: Homo sapiens
UniProt:
- Canonical:
P19388 (Residues: 1-210; Coverage: 100%)
Pfam:
InterPro:
Chain: F
Length: 127 amino acids
Theoretical weight: 14.49 KDa
Source organism: Homo sapiens
UniProt:
Pfam: RNA polymerase Rpb6
InterPro:
Length: 127 amino acids
Theoretical weight: 14.49 KDa
Source organism: Homo sapiens
UniProt:
- Canonical:
P61218 (Residues: 1-127; Coverage: 100%)
Pfam: RNA polymerase Rpb6
InterPro:
Chain: G
Length: 338 amino acids
Theoretical weight: 37.49 KDa
Source organism: Homo sapiens
UniProt:
Pfam:
InterPro:
Length: 338 amino acids
Theoretical weight: 37.49 KDa
Source organism: Homo sapiens
UniProt:
- Canonical:
Q3B726 (Residues: 1-338; Coverage: 100%)
Pfam:
InterPro:
Chain: H
Length: 150 amino acids
Theoretical weight: 17.16 KDa
Source organism: Homo sapiens
UniProt:
Pfam: RNA polymerase Rpb8
InterPro:
Length: 150 amino acids
Theoretical weight: 17.16 KDa
Source organism: Homo sapiens
UniProt:
- Canonical:
P52434 (Residues: 1-150; Coverage: 100%)
Pfam: RNA polymerase Rpb8
InterPro:
Chain: I
Length: 126 amino acids
Theoretical weight: 13.92 KDa
Source organism: Homo sapiens
UniProt:
Pfam: Transcription factor S-II (TFIIS)
InterPro:
Length: 126 amino acids
Theoretical weight: 13.92 KDa
Source organism: Homo sapiens
UniProt:
- Canonical:
Q9P1U0 (Residues: 1-126; Coverage: 100%)
Pfam: Transcription factor S-II (TFIIS)
InterPro:
Chain: J
Length: 67 amino acids
Theoretical weight: 7.66 KDa
Source organism: Homo sapiens
UniProt:
Pfam: RNA polymerases N / 8 kDa subunit
InterPro:
Length: 67 amino acids
Theoretical weight: 7.66 KDa
Source organism: Homo sapiens
UniProt:
- Canonical:
P62875 (Residues: 1-67; Coverage: 100%)
Pfam: RNA polymerases N / 8 kDa subunit
InterPro:
Chain: K
Length: 133 amino acids
Theoretical weight: 15.26 KDa
Source organism: Homo sapiens
UniProt:
Pfam: RNA polymerase Rpb3/Rpb11 dimerisation domain
InterPro:
Length: 133 amino acids
Theoretical weight: 15.26 KDa
Source organism: Homo sapiens
UniProt:
- Canonical:
P0DPB6 (Residues: 1-133; Coverage: 100%)
Pfam: RNA polymerase Rpb3/Rpb11 dimerisation domain
InterPro:
Chain: L
Length: 58 amino acids
Theoretical weight: 7.02 KDa
Source organism: Homo sapiens
UniProt:
Pfam: DNA directed RNA polymerase, 7 kDa subunit
InterPro:
Length: 58 amino acids
Theoretical weight: 7.02 KDa
Source organism: Homo sapiens
UniProt:
- Canonical:
P53803 (Residues: 1-58; Coverage: 100%)
Pfam: DNA directed RNA polymerase, 7 kDa subunit
InterPro:
Chain: M
Length: 419 amino acids
Theoretical weight: 47.33 KDa
Source organism: Homo sapiens
UniProt:
Pfam: A49-like RNA polymerase I associated factor
InterPro: RNA polymerase I associated factor, A49-like
Length: 419 amino acids
Theoretical weight: 47.33 KDa
Source organism: Homo sapiens
UniProt:
- Canonical:
Q9GZS1 (Residues: 1-419; Coverage: 100%)
Pfam: A49-like RNA polymerase I associated factor
InterPro: RNA polymerase I associated factor, A49-like
Chain: N
Length: 510 amino acids
Theoretical weight: 55.07 KDa
Source organism: Homo sapiens
UniProt: Gene names: ASE1, CAST, CD3EAP, PAF49, POLR1G
Pfam: DNA-directed RNA polymerase I subunit RPA34.5
InterPro: DNA-directed RNA polymerase I, subunit RPA34
Length: 510 amino acids
Theoretical weight: 55.07 KDa
Source organism: Homo sapiens
UniProt: Gene names: ASE1, CAST, CD3EAP, PAF49, POLR1G
Pfam: DNA-directed RNA polymerase I subunit RPA34.5
InterPro: DNA-directed RNA polymerase I, subunit RPA34
Name:
DNA template strand
Representative chains: T
Length: 43 nucleotides
Theoretical weight: 13.27 KDa
Representative chains: T
Length: 43 nucleotides
Theoretical weight: 13.27 KDa
Name:
DNA non-template strand
Representative chains: S
Length: 43 nucleotides
Theoretical weight: 13.27 KDa
Representative chains: S
Length: 43 nucleotides
Theoretical weight: 13.27 KDa