› 7oil

X-ray diffraction
1.95Å resolution

Function and Biology Details

Reactions catalysed: 
ATP + 1-phosphatidyl-1D-myo-inositol = ADP + 1-phosphatidyl-1D-myo-inositol 3-phosphate
ATP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate = ADP + 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-128718 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform Chain: AAA
Molecule details ›
Chain: AAA
Length: 1084 amino acids
Theoretical weight: 124.83 KDa
Source organism: Mus musculus
Expression system: Insect cell expression vector pTIE1
UniProt:
  • Canonical: O35904 (Residues: 1-105, 106-507, 509-1043; Coverage: 100%)
Gene name: Pik3cd
Sequence domains:

Ligands and Environments

2 bound ligands:
Ligand NA 1 x NA
Ligand VEN 1 x VEN
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU FR-E
Spacegroup: C2
Unit cell:
a: 142.01Å b: 64.75Å c: 116.38Å
α: 90° β: 103.39° γ: 90°
R-values:
R R work R free
0.241 0.239 0.289
Expression system: Insect cell expression vector pTIE1

Quick links

Citations

3 review citations

PI3K inhibitors are finally coming of age.
Vanhaesebroeck et al. (2021)
2 more

1 mention without citation

Structural Insights from Molecular Modeling of Isoindolin-1-One Derivatives as PI3Kγ Inhibitors against Gastric Carcinoma.
Ghosh et al. (2022)