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Crystal structure of haspin in complex with ZW282 (compound 2a)

X-ray diffraction
2.38Å resolution
PDB entry 7ops coloured by chain, front view.
PDB entry 7ops coloured by chain, side view.
PDB entry 7ops coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Serine/threonine-protein kinase haspin
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Multimeric state: monomeric
Accessible surface area: 15531.73 Å2
Buried surface area: 292.31 Å2
Dissociation area: 146.15 Å2
Dissociation energy (ΔGdiss): 1.66 kcal/mol
Dissociation entropy (TΔSdiss): 0.95 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-186268

Macromolecules

Serine/threonine-protein kinase haspin
Chain: A
Length: 357 amino acids
Theoretical weight: 40.71 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q8TF76 (Residues: 465-798; Coverage: 42%)
Gene names: GSG2, HASPIN
Pfam: Haspin like kinase domain
InterPro:
Serine/threonine-protein kinase haspin in PDB entry 7ops, assembly 1, front view.
Serine/threonine-protein kinase haspin in PDB entry 7ops, assembly 1, side view.
Serine/threonine-protein kinase haspin in PDB entry 7ops, assembly 1, top view.
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