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Crystal structure of YTHDC1 with compound YLI_DC1_001

X-ray diffraction
1.3Å resolution
PDB entry 7p87 coloured by chain, front view.
PDB entry 7p87 coloured by chain, side view.
PDB entry 7p87 coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: YTH domain-containing protein 1
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Multimeric state: monomeric
Accessible surface area: 8313.91 Å2
Buried surface area: 472.67 Å2
Dissociation area: 67.4 Å2
Dissociation energy (ΔGdiss): 9.25 kcal/mol
Dissociation entropy (TΔSdiss): 0.59 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-188634
Assembly 2
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Assembly Name: YTH domain-containing protein 1
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Multimeric state: monomeric
Accessible surface area: 8496.44 Å2
Buried surface area: 564.75 Å2
Dissociation area: 56.41 Å2
Dissociation energy (ΔGdiss): 6.91 kcal/mol
Dissociation entropy (TΔSdiss): 0.57 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-188634

Macromolecules

YTH domain-containing protein 1
Chains: A, B
Length: 183 amino acids
Theoretical weight: 20.97 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q96MU7 (Residues: 345-509; Coverage: 23%)
Gene names: KIAA1966, YT521, YTHDC1
Pfam: YT521-B-like domain
InterPro:
YTH domain-containing protein 1 in PDB entry 7p87, assembly 1, front view.
YTH domain-containing protein 1 in PDB entry 7p87, assembly 1, side view.
YTH domain-containing protein 1 in PDB entry 7p87, assembly 1, top view.
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