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TmHydABC- T. maritima bifurcating hydrogenase with bridge domain closed

Source organism: Thermotoga maritima MSB8
Biochemical function: metal ion binding
Biological process: proton transmembrane transport
Cellular component: cytoplasm

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EC 1.12.1.4: Hydrogenase (NAD(+), ferredoxin)

Reaction catalysed:
2 H(2) + NAD(+) + 2 oxidized ferredoxin = 5 H(+) + NADH + 2 reduced ferredoxin
Systematic name:
Hydrogen:NAD(+), ferredoxin oxidoreductase
Alternative Name(s):
  • Bifurcating (FeFe) hydrogenase

GO terms

Biochemical function:
Biological process:
Cellular component:

Sequence families

Pfam Protein families (Pfam)
PF01257
Domain description: Thioredoxin-like [2Fe-2S] ferredoxin
Occurring in:
  1. Bifurcating [FeFe] hydrogenase alpha subunit
  2. Bifurcating [FeFe] hydrogenase beta subunit
  3. Bifurcating [FeFe] hydrogenase gamma subunit
The deposited structure of PDB entry 7p91 contains 2 copies of Pfam domain PF01257 (Thioredoxin-like [2Fe-2S] ferredoxin) in Bifurcating [FeFe] hydrogenase alpha subunit. Showing 1 copy in chain A [auth a].
The deposited structure of PDB entry 7p91 contains 2 copies of Pfam domain PF01257 (Thioredoxin-like [2Fe-2S] ferredoxin) in Bifurcating [FeFe] hydrogenase beta subunit. Showing 1 copy in chain E [auth B].
The deposited structure of PDB entry 7p91 contains 2 copies of Pfam domain PF01257 (Thioredoxin-like [2Fe-2S] ferredoxin) in Bifurcating [FeFe] hydrogenase gamma subunit. Showing 1 copy in chain F [auth C].

PF00037
Domain description: 4Fe-4S binding domain
Occurring in:
  1. Bifurcating [FeFe] hydrogenase alpha subunit
  2. Bifurcating [FeFe] hydrogenase beta subunit
The deposited structure of PDB entry 7p91 contains 2 copies of Pfam domain PF00037 (4Fe-4S binding domain) in Bifurcating [FeFe] hydrogenase alpha subunit. Showing 1 copy in chain A [auth a].
The deposited structure of PDB entry 7p91 contains 4 copies of Pfam domain PF00037 (4Fe-4S binding domain) in Bifurcating [FeFe] hydrogenase beta subunit. Showing 2 copies in chain E [auth B].

PF10589
Domain description: NADH-ubiquinone oxidoreductase-F iron-sulfur binding region
Occurring in:
  1. Bifurcating [FeFe] hydrogenase beta subunit
The deposited structure of PDB entry 7p91 contains 2 copies of Pfam domain PF10589 (NADH-ubiquinone oxidoreductase-F iron-sulfur binding region) in Bifurcating [FeFe] hydrogenase beta subunit. Showing 1 copy in chain E [auth B].

PF01512
Domain description: Respiratory-chain NADH dehydrogenase 51 Kd subunit
Occurring in:
  1. Bifurcating [FeFe] hydrogenase beta subunit
The deposited structure of PDB entry 7p91 contains 2 copies of Pfam domain PF01512 (Respiratory-chain NADH dehydrogenase 51 Kd subunit) in Bifurcating [FeFe] hydrogenase beta subunit. Showing 1 copy in chain E [auth B].

PF02256
Domain description: Iron hydrogenase small subunit
Occurring in:
  1. Bifurcating [FeFe] hydrogenase alpha subunit
The deposited structure of PDB entry 7p91 contains 2 copies of Pfam domain PF02256 (Iron hydrogenase small subunit) in Bifurcating [FeFe] hydrogenase alpha subunit. Showing 1 copy in chain A [auth a].

PF02906
Domain description: Iron only hydrogenase large subunit, C-terminal domain
Occurring in:
  1. Bifurcating [FeFe] hydrogenase alpha subunit
The deposited structure of PDB entry 7p91 contains 2 copies of Pfam domain PF02906 (Iron only hydrogenase large subunit, C-terminal domain) in Bifurcating [FeFe] hydrogenase alpha subunit. Showing 1 copy in chain A [auth a].

PF10588
Domain description: NADH-ubiquinone oxidoreductase-G iron-sulfur binding region
Occurring in:
  1. Bifurcating [FeFe] hydrogenase alpha subunit
The deposited structure of PDB entry 7p91 contains 2 copies of Pfam domain PF10588 (NADH-ubiquinone oxidoreductase-G iron-sulfur binding region) in Bifurcating [FeFe] hydrogenase alpha subunit. Showing 1 copy in chain A [auth a].

PF00111
Domain description: 2Fe-2S iron-sulfur cluster binding domain
Occurring in:
  1. Bifurcating [FeFe] hydrogenase alpha subunit
The deposited structure of PDB entry 7p91 contains 2 copies of Pfam domain PF00111 (2Fe-2S iron-sulfur cluster binding domain) in Bifurcating [FeFe] hydrogenase alpha subunit. Showing 1 copy in chain A [auth a].

InterPro InterPro annotations
IPR017896
Domain description: 4Fe-4S ferredoxin-type, iron-sulphur binding domain
Occurring in:
  1. Bifurcating [FeFe] hydrogenase alpha subunit
  2. Bifurcating [FeFe] hydrogenase beta subunit
IPR036249
Domain description: Thioredoxin-like superfamily
Occurring in:
  1. Bifurcating [FeFe] hydrogenase alpha subunit
  2. Bifurcating [FeFe] hydrogenase beta subunit
  3. Bifurcating [FeFe] hydrogenase gamma subunit
IPR017900
Domain description: 4Fe-4S ferredoxin, iron-sulphur binding, conserved site
Occurring in:
  1. Bifurcating [FeFe] hydrogenase alpha subunit
  2. Bifurcating [FeFe] hydrogenase beta subunit
IPR019574
Domain description: NADH:ubiquinone oxidoreductase, subunit G, iron-sulphur binding
Occurring in:
  1. Bifurcating [FeFe] hydrogenase alpha subunit
IPR002023
Domain description: NADH-quinone oxidoreductase subunit E-like
Occurring in:
  1. Bifurcating [FeFe] hydrogenase gamma subunit
IPR019575
Domain description: NADH-ubiquinone oxidoreductase 51kDa subunit, iron-sulphur binding domain
Occurring in:
  1. Bifurcating [FeFe] hydrogenase beta subunit
IPR037207
Domain description: NADH-ubiquinone oxidoreductase 51kDa subunit, iron-sulphur binding domain superfamily
Occurring in:
  1. Bifurcating [FeFe] hydrogenase beta subunit
IPR037225
Domain description: NADH-ubiquinone oxidoreductase 51kDa subunit, FMN-binding domain superfamily
Occurring in:
  1. Bifurcating [FeFe] hydrogenase beta subunit
IPR003149
Domain description: Iron hydrogenase, small subunit
Occurring in:
  1. Bifurcating [FeFe] hydrogenase alpha subunit
IPR001041
Domain description: 2Fe-2S ferredoxin-type iron-sulfur binding domain
Occurring in:
  1. Bifurcating [FeFe] hydrogenase alpha subunit
IPR042128
Domain description: NuoE domain
Occurring in:
  1. Bifurcating [FeFe] hydrogenase gamma subunit
IPR041921
Domain description: NADH-quinone oxidoreductase subunit E, N-terminal
Occurring in:
  1. Bifurcating [FeFe] hydrogenase gamma subunit
IPR028431
Domain description: NADP-reducing hydrogenase subunit HndA-like
Occurring in:
  1. Bifurcating [FeFe] hydrogenase gamma subunit
IPR001949
Domain description: NADH:ubiquinone oxidoreductase, 51kDa subunit, conserved site
Occurring in:
  1. Bifurcating [FeFe] hydrogenase beta subunit
IPR011538
Domain description: NADH-ubiquinone oxidoreductase 51kDa subunit, FMN-binding domain
Occurring in:
  1. Bifurcating [FeFe] hydrogenase beta subunit
IPR004108
Domain description: Iron hydrogenase, large subunit, C-terminal
Occurring in:
  1. Bifurcating [FeFe] hydrogenase alpha subunit
IPR009016
Domain description: Iron hydrogenase
Occurring in:
  1. Bifurcating [FeFe] hydrogenase alpha subunit
IPR000283
Domain description: NADH:ubiquinone oxidoreductase, 75kDa subunit, conserved site
Occurring in:
  1. Bifurcating [FeFe] hydrogenase alpha subunit
IPR036010
Domain description: 2Fe-2S ferredoxin-like superfamily
Occurring in:
  1. Bifurcating [FeFe] hydrogenase alpha subunit

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