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cryo-EM structure of DEPTOR bound to human mTOR complex 1, focussed on one protomer

Electron Microscopy
3.67Å resolution
PDB entry 7peb coloured by chain, front view.
PDB entry 7peb coloured by chain, side view.
PDB entry 7peb coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
hetero tetramer (preferred)
Entry contents: 4 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Multimeric state: hetero tetramer
Accessible surface area: 165987.96 Å2
Buried surface area: 6215.12 Å2
Dissociation area: 2,770.07 Å2
Dissociation energy (ΔGdiss): -15.15 kcal/mol
Dissociation entropy (TΔSdiss): 43.75 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-154625

Macromolecules

Serine/threonine-protein kinase mTOR
Chain: A
Length: 2549 amino acids
Theoretical weight: 287.48 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P42345 (Residues: 1-2549; Coverage: 100%)
Gene names: FRAP, FRAP1, FRAP2, MTOR, RAFT1, RAPT1
Pfam:
InterPro:
Serine/threonine-protein kinase mTOR in PDB entry 7peb, assembly 1, front view.
Serine/threonine-protein kinase mTOR in PDB entry 7peb, assembly 1, side view.
Serine/threonine-protein kinase mTOR in PDB entry 7peb, assembly 1, top view.
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Target of rapamycin complex subunit LST8
Chain: C
Length: 326 amino acids
Theoretical weight: 35.91 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q9BVC4 (Residues: 1-326; Coverage: 100%)
Gene names: GBL, LST8, MLST8
Pfam: WD domain, G-beta repeat
InterPro:
Target of rapamycin complex subunit LST8 in PDB entry 7peb, assembly 1, front view.
Target of rapamycin complex subunit LST8 in PDB entry 7peb, assembly 1, side view.
Target of rapamycin complex subunit LST8 in PDB entry 7peb, assembly 1, top view.
Molecule details ›

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Regulatory-associated protein of mTOR
Chain: E
Length: 1396 amino acids
Theoretical weight: 155.96 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q8N122 (Residues: 1-1335; Coverage: 100%)
Gene names: KIAA1303, RAPTOR, RPTOR
Pfam:
InterPro:
Regulatory-associated protein of mTOR in PDB entry 7peb, assembly 1, front view.
Regulatory-associated protein of mTOR in PDB entry 7peb, assembly 1, side view.
Regulatory-associated protein of mTOR in PDB entry 7peb, assembly 1, top view.
Molecule details ›

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DEP domain-containing mTOR-interacting protein
Chain: I
Length: 409 amino acids
Theoretical weight: 46.37 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q8TB45 (Residues: 1-409; Coverage: 100%)
Gene names: DEPDC6, DEPTOR
Pfam: Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP)
InterPro:
DEP domain-containing mTOR-interacting protein in PDB entry 7peb, assembly 1, front view.
DEP domain-containing mTOR-interacting protein in PDB entry 7peb, assembly 1, side view.
DEP domain-containing mTOR-interacting protein in PDB entry 7peb, assembly 1, top view.
Molecule details ›

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