Function and Biology

CARM1 in complex with EML982

Source organism: Mus musculus
Biochemical function: protein-arginine N-methyltransferase activity
Biological process: peptidyl-arginine methylation
Cellular component: not assigned

EC 2.1.1.319: Type I protein arginine methyltransferase

Reaction catalysed:
(1a) S-adenosyl-L-methionine + [protein]-L-arginine = S-adenosyl-L-homocysteine + [protein]-N(omega)-methyl-L-arginine
Systematic name:
S-adenosyl-L-methionine:[protein]-L-arginine N-methyltransferase ([protein]-N(omega),N(omega)-dimethyl-L-arginine-forming)
Alternative Name(s):
  • CARM1 (gene name)
  • PRMT1 (gene name)
  • PRMT2 (gene name)
  • PRMT3 (gene name)
  • PRMT4 (gene name)
  • PRMT6 (gene name)
  • PRMT8 (gene name)
  • RMT1 (gene name)

GO terms

Biochemical function:
Biological process:
Cellular component:
  • not assigned

Sequence families

Pfam Protein families (Pfam)
PF22528
Domain description: Arginine methyltransferase oligomerization subdomain
Occurring in:
  1. Histone-arginine methyltransferase CARM1

PF06325
Domain description: Ribosomal protein L11 methyltransferase (PrmA)
Occurring in:
  1. Histone-arginine methyltransferase CARM1
The deposited structure of PDB entry 7puq contains 4 copies of Pfam domain PF06325 (Ribosomal protein L11 methyltransferase (PrmA)) in Histone-arginine methyltransferase CARM1. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR025799
Domain description: Protein arginine N-methyltransferase
Occurring in:
  1. Histone-arginine methyltransferase CARM1
IPR029063
Domain description: S-adenosyl-L-methionine-dependent methyltransferase superfamily
Occurring in:
  1. Histone-arginine methyltransferase CARM1