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CARM1 in complex with EML982

X-ray diffraction
2.09Å resolution
PDB entry 7puq coloured by chain, front view.
PDB entry 7puq coloured by chain, side view.
PDB entry 7puq coloured by chain, top view.
Source organism: Mus musculus
Assembly composition:
homo tetramer (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Histone-arginine methyltransferase CARM1
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Multimeric state: homo tetramer
Accessible surface area: 50361.77 Å2
Buried surface area: 10087.55 Å2
Dissociation area: 4,543.33 Å2
Dissociation energy (ΔGdiss): 27.76 kcal/mol
Dissociation entropy (TΔSdiss): 43.36 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-194407

Macromolecules

Histone-arginine methyltransferase CARM1
Chains: A, B, C, D
Length: 360 amino acids
Theoretical weight: 40.79 KDa
Source organism: Mus musculus
Expression system: Spodoptera aff. frugiperda 1 BOLD-2017
UniProt:
  • Canonical: Q9WVG6 (Residues: 130-486; Coverage: 59%)
Gene names: Carm1, Prmt4
Pfam:
InterPro:
Histone-arginine methyltransferase CARM1 in PDB entry 7puq, assembly 1, front view.
Histone-arginine methyltransferase CARM1 in PDB entry 7puq, assembly 1, side view.
Histone-arginine methyltransferase CARM1 in PDB entry 7puq, assembly 1, top view.
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