Assemblies
Assembly Name:
SMG1C protein kinase complex
Multimeric state:
hetero trimer
Accessible surface area:
115312.52 Å2
Buried surface area:
12183.81 Å2
Dissociation area:
2,943.82
Å2
Dissociation energy (ΔGdiss):
29.13
kcal/mol
Dissociation entropy (TΔSdiss):
16.38
kcal/mol
Symmetry number:
1
PDBe Complex ID:
PDB-CPX-185493
Macromolecules
Chain: A
Length: 3657 amino acids
Theoretical weight: 397.4 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
Pfam:
InterPro:
Length: 3657 amino acids
Theoretical weight: 397.4 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
- Canonical:
Q96Q15 (Residues: 311-3661; Coverage: 92%)
Pfam:
InterPro:
- Serine/threonine-protein kinase SMG1
- Armadillo-type fold
- PIK-related kinase
- Protein kinase-like domain superfamily
- SMG1, PIKK catalytic domain
- Phosphatidylinositol 3-/4-kinase, catalytic domain
- Phosphatidylinositol 3-/4-kinase, catalytic domain superfamily
- Phosphatidylinositol 3/4-kinase, conserved site
- FATC domain
Chain: B
Length: 991 amino acids
Theoretical weight: 109.83 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
Pfam: Smg8_Smg9
InterPro:
Length: 991 amino acids
Theoretical weight: 109.83 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
- Canonical: Q8ND04 (Residues: 1-991; Coverage: 100%)
Pfam: Smg8_Smg9
InterPro:
Chain: C
Length: 520 amino acids
Theoretical weight: 57.72 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
InterPro:
Length: 520 amino acids
Theoretical weight: 57.72 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
- Canonical: Q9H0W8 (Residues: 1-520; Coverage: 100%)
InterPro:
