› 7q2m

X-ray diffraction
2.08Å resolution

Crystal structure of the C-terminal catalytic domain of Plasmodium falciparum CTP:phosphocholine cytidylyltransferase with but-3-yn-2-amine hydrochloride

Released:
DOI: 10.2210/pdb7q2m/pdb
PDB entry 7q2m coloured by chain, front view.
PDB entry 7q2m coloured by chain, side view.
PDB entry 7q2m coloured by chain, top view.
Source organism: Plasmodium falciparum
Entry authors: Duclovel C, Gelin M, Krimm I, Cerdan R, Guichou JF

Function and Biology Details

Reaction catalysed: 
CTP + phosphocholine = diphosphate + CDP-choline
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-184754 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
choline-phosphate cytidylyltransferase Chain: A
Molecule details ›
Chain: A
Length: 180 amino acids
Theoretical weight: 20.81 KDa
Source organism: Plasmodium falciparum
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q8IEE9 (Residues: 581-775; Coverage: 20%)
Gene name: PF3D7_1316600
Sequence domains: Cytidylyltransferase-like

Ligands and Environments

1 bound ligand:
Ligand 8PN 2 x 8PN
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE MASSIF-1
Spacegroup: I222
Unit cell:
a: 50.3Å b: 68.991Å c: 117.534Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.21 0.209 0.234
Expression system: Escherichia coli BL21(DE3)

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