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Crystal structure of the C-terminal catalytic domain of Plasmodium falciparum CTP:phosphocholine cytidylyltransferase with but-3-yn-2-amine hydrochloride

X-ray diffraction
2.08Å resolution
PDB entry 7q2m coloured by chain, front view.
PDB entry 7q2m coloured by chain, side view.
PDB entry 7q2m coloured by chain, top view.
Source organism: Plasmodium falciparum
Assembly composition:
homo dimer (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: choline-phosphate cytidylyltransferase
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Multimeric state: homo dimer
Accessible surface area: 14259.36 Å2
Buried surface area: 2199.14 Å2
Dissociation area: 1,099.57 Å2
Dissociation energy (ΔGdiss): 7.93 kcal/mol
Dissociation entropy (TΔSdiss): 11.94 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-184754

Macromolecules

choline-phosphate cytidylyltransferase
Chain: A
Length: 180 amino acids
Theoretical weight: 20.81 KDa
Source organism: Plasmodium falciparum
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q8IEE9 (Residues: 581-775; Coverage: 20%)
Gene name: PF3D7_1316600
Pfam: Cytidylyltransferase-like
InterPro:
choline-phosphate cytidylyltransferase in PDB entry 7q2m, assembly 1, front view.
choline-phosphate cytidylyltransferase in PDB entry 7q2m, assembly 1, side view.
choline-phosphate cytidylyltransferase in PDB entry 7q2m, assembly 1, top view.
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