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Structure of the activation intermediate of cathepsin K in complex with the azadipeptide nitrile inhibitor Gu1303

X-ray diffraction
1.9Å resolution
PDB entry 7qbo coloured by chain, front view.
PDB entry 7qbo coloured by chain, side view.
PDB entry 7qbo coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
hetero dimer (preferred)
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Cathepsin K
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Multimeric state: hetero dimer
Accessible surface area: 13470.78 Å2
Buried surface area: 2793.37 Å2
Dissociation area: 1,028.56 Å2
Dissociation energy (ΔGdiss): 2.94 kcal/mol
Dissociation entropy (TΔSdiss): 11.06 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-154997

Macromolecules

Cathepsin K
Chain: A
Length: 216 amino acids
Theoretical weight: 23.68 KDa
Source organism: Homo sapiens
Expression system: Komagataella phaffii GS115
UniProt:
  • Canonical: P43235 (Residues: 114-329; Coverage: 69%)
Gene names: CTSK, CTSO, CTSO2
Pfam: Papain family cysteine protease
InterPro:
Cathepsin K in PDB entry 7qbo, assembly 1, front view.
Cathepsin K in PDB entry 7qbo, assembly 1, side view.
Cathepsin K in PDB entry 7qbo, assembly 1, top view.
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Cathepsin K
Chain: P
Length: 74 amino acids
Theoretical weight: 8.98 KDa
Source organism: Homo sapiens
Expression system: Komagataella phaffii GS115
UniProt:
  • Canonical: P43235 (Residues: 16-89; Coverage: 24%)
Gene names: CTSK, CTSO, CTSO2
Pfam: Cathepsin propeptide inhibitor domain (I29)
InterPro:
Cathepsin K in PDB entry 7qbo, assembly 1, front view.
Cathepsin K in PDB entry 7qbo, assembly 1, side view.
Cathepsin K in PDB entry 7qbo, assembly 1, top view.
Molecule details ›

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