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Cryo-EM structure of the human mtLSU assembly intermediate upon MRM2 depletion - class 4

Electron Microscopy
2.89Å resolution
PDB entry 7qh7 coloured by chain, front view.
PDB entry 7qh7 coloured by chain, side view.
PDB entry 7qh7 coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
hetero 49-mer (preferred)
Entry contents: 47 distinct polypeptide molecules
2 distinct RNA molecules

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Assemblies

Assembly 1 (preferred)
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Multimeric state: hetero 49-mer
Accessible surface area: 444342.91 Å2
Buried surface area: 283674.38 Å2
Dissociation area: 668 Å2
Dissociation energy (ΔGdiss): -6.27 kcal/mol
Dissociation entropy (TΔSdiss): 11.77 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-125781

Macromolecules

Large ribosomal subunit protein uL2m
Chain: D
Length: 215 amino acids
Theoretical weight: 23.83 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q5T653 (Residues: 61-275; Coverage: 71%)
Gene names: CGI-22, MRPL2
Pfam:
InterPro:
Large ribosomal subunit protein uL2m in PDB entry 7qh7, assembly 1, front view.
Large ribosomal subunit protein uL2m in PDB entry 7qh7, assembly 1, side view.
Large ribosomal subunit protein uL2m in PDB entry 7qh7, assembly 1, top view.
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Large ribosomal subunit protein uL3m
Chain: E
Length: 304 amino acids
Theoretical weight: 34.02 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P09001 (Residues: 45-348; Coverage: 87%)
Gene names: MRL3, MRPL3, RPML3
Pfam: Ribosomal protein L3
InterPro:
Large ribosomal subunit protein uL3m in PDB entry 7qh7, assembly 1, front view.
Large ribosomal subunit protein uL3m in PDB entry 7qh7, assembly 1, side view.
Large ribosomal subunit protein uL3m in PDB entry 7qh7, assembly 1, top view.
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Large ribosomal subunit protein uL4m
Chain: F
Length: 250 amino acids
Theoretical weight: 28.53 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q9BYD3 (Residues: 45-294; Coverage: 80%)
Gene names: CDABP0091, CGI-28, MRPL4
Pfam: Ribosomal protein L4/L1 family
InterPro:
Large ribosomal subunit protein uL4m in PDB entry 7qh7, assembly 1, front view.
Large ribosomal subunit protein uL4m in PDB entry 7qh7, assembly 1, side view.
Large ribosomal subunit protein uL4m in PDB entry 7qh7, assembly 1, top view.
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Large ribosomal subunit protein bL9m
Chain: H
Length: 95 amino acids
Theoretical weight: 11.13 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q9BYD2 (Residues: 53-147; Coverage: 36%)
Gene name: MRPL9
Pfam: Ribosomal protein L9, N-terminal domain
InterPro:
Large ribosomal subunit protein bL9m in PDB entry 7qh7, assembly 1, front view.
Large ribosomal subunit protein bL9m in PDB entry 7qh7, assembly 1, side view.
Large ribosomal subunit protein bL9m in PDB entry 7qh7, assembly 1, top view.
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Large ribosomal subunit protein uL10m
Chain: I
Length: 30 amino acids
Theoretical weight: 3.55 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q7Z7H8 (Residues: 37-66; Coverage: 12%)
Gene names: MRPL10, MRPL8, RPML8
InterPro: Large ribosomal subunit protein uL10-like domain superfamily
Large ribosomal subunit protein uL10m in PDB entry 7qh7, assembly 1, front view.
Large ribosomal subunit protein uL10m in PDB entry 7qh7, assembly 1, side view.
Large ribosomal subunit protein uL10m in PDB entry 7qh7, assembly 1, top view.
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Large ribosomal subunit protein uL13m
Chain: K
Length: 177 amino acids
Theoretical weight: 20.59 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q9BYD1 (Residues: 2-178; Coverage: 99%)
Gene name: MRPL13
Pfam: Ribosomal protein L13
InterPro:
Large ribosomal subunit protein uL13m in PDB entry 7qh7, assembly 1, front view.
Large ribosomal subunit protein uL13m in PDB entry 7qh7, assembly 1, side view.
Large ribosomal subunit protein uL13m in PDB entry 7qh7, assembly 1, top view.
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Large ribosomal subunit protein uL14m
Chain: L
Length: 115 amino acids
Theoretical weight: 12.71 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q6P1L8 (Residues: 31-145; Coverage: 79%)
Gene names: MRPL14, MRPL32, RPML32
Pfam: Ribosomal protein L14p/L23e
InterPro:
Large ribosomal subunit protein uL14m in PDB entry 7qh7, assembly 1, front view.
Large ribosomal subunit protein uL14m in PDB entry 7qh7, assembly 1, side view.
Large ribosomal subunit protein uL14m in PDB entry 7qh7, assembly 1, top view.
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Large ribosomal subunit protein uL15m
Chain: M
Length: 287 amino acids
Theoretical weight: 32.7 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q9P015 (Residues: 10-296; Coverage: 97%)
Gene names: HSPC145, MRPL15
Pfam: Ribosomal proteins 50S-L15, 50S-L18e, 60S-L27A
InterPro:
Large ribosomal subunit protein uL15m in PDB entry 7qh7, assembly 1, front view.
Large ribosomal subunit protein uL15m in PDB entry 7qh7, assembly 1, side view.
Large ribosomal subunit protein uL15m in PDB entry 7qh7, assembly 1, top view.
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Large ribosomal subunit protein uL16m
Chain: N
Length: 201 amino acids
Theoretical weight: 23.07 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q9NX20 (Residues: 51-251; Coverage: 80%)
Gene names: MRPL16, PNAS-111
Pfam: Ribosomal protein L16p/L10e
InterPro:
Large ribosomal subunit protein uL16m in PDB entry 7qh7, assembly 1, front view.
Large ribosomal subunit protein uL16m in PDB entry 7qh7, assembly 1, side view.
Large ribosomal subunit protein uL16m in PDB entry 7qh7, assembly 1, top view.
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Large ribosomal subunit protein bL17m
Chain: O
Length: 152 amino acids
Theoretical weight: 17.76 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q9NRX2 (Residues: 9-160; Coverage: 87%)
Gene names: LIP2, MRPL17
Pfam: Ribosomal protein L17
InterPro:
Large ribosomal subunit protein bL17m in PDB entry 7qh7, assembly 1, front view.
Large ribosomal subunit protein bL17m in PDB entry 7qh7, assembly 1, side view.
Large ribosomal subunit protein bL17m in PDB entry 7qh7, assembly 1, top view.
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Large ribosomal subunit protein uL18m
Chain: P
Length: 141 amino acids
Theoretical weight: 16.34 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q9H0U6 (Residues: 39-179; Coverage: 78%)
Gene names: HSPC071, MRPL18
Pfam: Ribosomal L18 of archaea, bacteria, mitoch. and chloroplast
InterPro:
Large ribosomal subunit protein uL18m in PDB entry 7qh7, assembly 1, front view.
Large ribosomal subunit protein uL18m in PDB entry 7qh7, assembly 1, side view.
Large ribosomal subunit protein uL18m in PDB entry 7qh7, assembly 1, top view.
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Large ribosomal subunit protein bL19m
Chain: Q
Length: 217 amino acids
Theoretical weight: 25.67 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P49406 (Residues: 74-290; Coverage: 74%)
Gene names: KIAA0104, MRPL15, MRPL19
Pfam: Ribosomal protein L19
InterPro:
Large ribosomal subunit protein bL19m in PDB entry 7qh7, assembly 1, front view.
Large ribosomal subunit protein bL19m in PDB entry 7qh7, assembly 1, side view.
Large ribosomal subunit protein bL19m in PDB entry 7qh7, assembly 1, top view.
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Large ribosomal subunit protein bL20m
Chain: R
Length: 139 amino acids
Theoretical weight: 16.25 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q9BYC9 (Residues: 10-148; Coverage: 93%)
Gene name: MRPL20
Pfam: Ribosomal protein L20
InterPro:
Large ribosomal subunit protein bL20m in PDB entry 7qh7, assembly 1, front view.
Large ribosomal subunit protein bL20m in PDB entry 7qh7, assembly 1, side view.
Large ribosomal subunit protein bL20m in PDB entry 7qh7, assembly 1, top view.
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Large ribosomal subunit protein bL21m
Chain: S
Length: 156 amino acids
Theoretical weight: 17.79 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q7Z2W9 (Residues: 49-204; Coverage: 76%)
Gene name: MRPL21
Pfam: Ribosomal prokaryotic L21 protein
InterPro:
Large ribosomal subunit protein bL21m in PDB entry 7qh7, assembly 1, front view.
Large ribosomal subunit protein bL21m in PDB entry 7qh7, assembly 1, side view.
Large ribosomal subunit protein bL21m in PDB entry 7qh7, assembly 1, top view.
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Large ribosomal subunit protein uL22m
Chain: T
Length: 166 amino acids
Theoretical weight: 19.47 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q9NWU5 (Residues: 41-206; Coverage: 81%)
Gene names: HSPC158, MRPL22, MRPL25, RPML25
Pfam: Ribosomal protein L22p/L17e
InterPro:
Large ribosomal subunit protein uL22m in PDB entry 7qh7, assembly 1, front view.
Large ribosomal subunit protein uL22m in PDB entry 7qh7, assembly 1, side view.
Large ribosomal subunit protein uL22m in PDB entry 7qh7, assembly 1, top view.
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Large ribosomal subunit protein uL23m
Chain: U
Length: 125 amino acids
Theoretical weight: 14.56 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q16540 (Residues: 2-153; Coverage: 82%)
Gene names: L23MRP, MRPL23, RPL23L
Pfam: Ribosomal protein L23
InterPro:
Large ribosomal subunit protein uL23m in PDB entry 7qh7, assembly 1, front view.
Large ribosomal subunit protein uL23m in PDB entry 7qh7, assembly 1, side view.
Large ribosomal subunit protein uL23m in PDB entry 7qh7, assembly 1, top view.
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Large ribosomal subunit protein uL24m
Chain: V
Length: 48 amino acids
Theoretical weight: 5.75 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q96A35 (Residues: 169-216; Coverage: 22%)
Gene name: MRPL24
Large ribosomal subunit protein uL24m in PDB entry 7qh7, assembly 1, front view.
Large ribosomal subunit protein uL24m in PDB entry 7qh7, assembly 1, side view.
Large ribosomal subunit protein uL24m in PDB entry 7qh7, assembly 1, top view.
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Large ribosomal subunit protein bL27m
Chain: W
Length: 100 amino acids
Theoretical weight: 11.36 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q9P0M9 (Residues: 49-148; Coverage: 68%)
Gene names: HSPC250, MRPL27
Pfam: Ribosomal L27 protein
InterPro: Large ribosomal subunit protein bL27
Large ribosomal subunit protein bL27m in PDB entry 7qh7, assembly 1, front view.
Large ribosomal subunit protein bL27m in PDB entry 7qh7, assembly 1, side view.
Large ribosomal subunit protein bL27m in PDB entry 7qh7, assembly 1, top view.
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Large ribosomal subunit protein bL28m
Chain: X
Length: 243 amino acids
Theoretical weight: 28.82 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q13084 (Residues: 2-244; Coverage: 95%)
Gene names: MAAT1, MRPL28
Pfam: Ribosomal L28 family
InterPro:
Large ribosomal subunit protein bL28m in PDB entry 7qh7, assembly 1, front view.
Large ribosomal subunit protein bL28m in PDB entry 7qh7, assembly 1, side view.
Large ribosomal subunit protein bL28m in PDB entry 7qh7, assembly 1, top view.
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Large ribosomal subunit protein uL29m
Chain: Y
Length: 175 amino acids
Theoretical weight: 21.36 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q9HD33 (Residues: 63-237; Coverage: 70%)
Gene names: CGI-204, MRPL47, NCM1
Pfam: Mitochondrial 39-S ribosomal protein L47 (MRP-L47)
InterPro:
Large ribosomal subunit protein uL29m in PDB entry 7qh7, assembly 1, front view.
Large ribosomal subunit protein uL29m in PDB entry 7qh7, assembly 1, side view.
Large ribosomal subunit protein uL29m in PDB entry 7qh7, assembly 1, top view.
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Large ribosomal subunit protein uL30m
Chain: Z
Length: 115 amino acids
Theoretical weight: 13.33 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q8TCC3 (Residues: 35-149; Coverage: 71%)
Gene names: HSPC249, MRPL28, MRPL30, RPML28
Pfam: Ribosomal protein L30p/L7e
InterPro:
Large ribosomal subunit protein uL30m in PDB entry 7qh7, assembly 1, front view.
Large ribosomal subunit protein uL30m in PDB entry 7qh7, assembly 1, side view.
Large ribosomal subunit protein uL30m in PDB entry 7qh7, assembly 1, top view.
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Large ribosomal subunit protein bL32m
Chain: 0
Length: 108 amino acids
Theoretical weight: 12.61 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q9BYC8 (Residues: 79-186; Coverage: 57%)
Gene names: HSPC283, MRPL32
Pfam: Ribosomal L32p protein family
InterPro:
Large ribosomal subunit protein bL32m in PDB entry 7qh7, assembly 1, front view.
Large ribosomal subunit protein bL32m in PDB entry 7qh7, assembly 1, side view.
Large ribosomal subunit protein bL32m in PDB entry 7qh7, assembly 1, top view.
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Large ribosomal subunit protein bL33m
Chain: 1
Length: 49 amino acids
Theoretical weight: 5.83 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: O75394 (Residues: 14-62; Coverage: 75%)
Gene names: C2orf1, MRPL33
Pfam: Ribosomal protein L33
InterPro:
Large ribosomal subunit protein bL33m in PDB entry 7qh7, assembly 1, front view.
Large ribosomal subunit protein bL33m in PDB entry 7qh7, assembly 1, side view.
Large ribosomal subunit protein bL33m in PDB entry 7qh7, assembly 1, top view.
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Large ribosomal subunit protein bL34m
Chain: 2
Length: 45 amino acids
Theoretical weight: 5.24 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q9BQ48 (Residues: 48-92; Coverage: 49%)
Gene name: MRPL34
Pfam: Ribosomal protein L34
InterPro: Large ribosomal subunit protein bL34
Large ribosomal subunit protein bL34m in PDB entry 7qh7, assembly 1, front view.
Large ribosomal subunit protein bL34m in PDB entry 7qh7, assembly 1, side view.
Large ribosomal subunit protein bL34m in PDB entry 7qh7, assembly 1, top view.
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Large ribosomal subunit protein bL35m
Chain: 3
Length: 95 amino acids
Theoretical weight: 11.79 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q9NZE8 (Residues: 94-188; Coverage: 51%)
Gene names: BM-007, MRPL35
Pfam: Ribosomal protein L35
InterPro:
Large ribosomal subunit protein bL35m in PDB entry 7qh7, assembly 1, front view.
Large ribosomal subunit protein bL35m in PDB entry 7qh7, assembly 1, side view.
Large ribosomal subunit protein bL35m in PDB entry 7qh7, assembly 1, top view.
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Large ribosomal subunit protein mL37
Chain: 5
Length: 392 amino acids
Theoretical weight: 45.3 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q9BZE1 (Residues: 31-422; Coverage: 93%)
Gene names: HSPC235, MRPL2, MRPL37, RPML2
Pfam: Mitochondrial 28S ribosomal protein S30 (PDCD9)
InterPro: Large ribosomal subunit protein mL37/mL65
Large ribosomal subunit protein mL37 in PDB entry 7qh7, assembly 1, front view.
Large ribosomal subunit protein mL37 in PDB entry 7qh7, assembly 1, side view.
Large ribosomal subunit protein mL37 in PDB entry 7qh7, assembly 1, top view.
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Large ribosomal subunit protein mL38
Chain: 6
Length: 292 amino acids
Theoretical weight: 34.73 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q96DV4 (Residues: 27-380; Coverage: 77%)
  • Best match: Q96DV4-2 (Residues: 1-196)
Gene names: HSPC262, MRPL38
Pfam: Phosphatidylethanolamine-binding protein
InterPro:
Large ribosomal subunit protein mL38 in PDB entry 7qh7, assembly 1, front view.
Large ribosomal subunit protein mL38 in PDB entry 7qh7, assembly 1, side view.
Large ribosomal subunit protein mL38 in PDB entry 7qh7, assembly 1, top view.
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Large ribosomal subunit protein mL39
Chain: 7
Length: 287 amino acids
Theoretical weight: 33.29 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q9NYK5 (Residues: 36-322; Coverage: 85%)
Gene names: C21orf92, MRPL39, MRPL5, MSTP003, PRED22, RPML5
InterPro:
Large ribosomal subunit protein mL39 in PDB entry 7qh7, assembly 1, front view.
Large ribosomal subunit protein mL39 in PDB entry 7qh7, assembly 1, side view.
Large ribosomal subunit protein mL39 in PDB entry 7qh7, assembly 1, top view.
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Large ribosomal subunit protein mL41
Chain: 9
Length: 123 amino acids
Theoretical weight: 14.03 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q8IXM3 (Residues: 15-137; Coverage: 90%)
Gene names: BMRP, MRPL27, MRPL41, PIG3, RPML27
Pfam: Mitochondrial ribosomal protein L27
InterPro: Large ribosomal subunit protein mL41
Large ribosomal subunit protein mL41 in PDB entry 7qh7, assembly 1, front view.
Large ribosomal subunit protein mL41 in PDB entry 7qh7, assembly 1, side view.
Large ribosomal subunit protein mL41 in PDB entry 7qh7, assembly 1, top view.
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Large ribosomal subunit protein mL42
Chain: a
Length: 80 amino acids
Theoretical weight: 9.58 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q9Y6G3 (Residues: 39-142; Coverage: 56%)
Gene names: HSPC204, MRPL31, MRPL42, MRPS32, PTD007, RPML31
Pfam: Mitochondrial 28S ribosomal protein S32
InterPro: Large ribosomal subunit protein mL42
Large ribosomal subunit protein mL42 in PDB entry 7qh7, assembly 1, front view.
Large ribosomal subunit protein mL42 in PDB entry 7qh7, assembly 1, side view.
Large ribosomal subunit protein mL42 in PDB entry 7qh7, assembly 1, top view.
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Large ribosomal subunit protein mL43
Chain: b
Length: 148 amino acids
Theoretical weight: 16.74 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q8N983 (Residues: 2-149; Coverage: 69%)
Gene name: MRPL43
Pfam: Mitochondrial ribosomal protein L51 / S25 / CI-B8 domain
InterPro:
Large ribosomal subunit protein mL43 in PDB entry 7qh7, assembly 1, front view.
Large ribosomal subunit protein mL43 in PDB entry 7qh7, assembly 1, side view.
Large ribosomal subunit protein mL43 in PDB entry 7qh7, assembly 1, top view.
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Large ribosomal subunit protein mL44
Chain: c
Length: 287 amino acids
Theoretical weight: 32.77 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q9H9J2 (Residues: 31-317; Coverage: 86%)
Gene name: MRPL44
Pfam:
InterPro:
Large ribosomal subunit protein mL44 in PDB entry 7qh7, assembly 1, front view.
Large ribosomal subunit protein mL44 in PDB entry 7qh7, assembly 1, side view.
Large ribosomal subunit protein mL44 in PDB entry 7qh7, assembly 1, top view.
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Large ribosomal subunit protein mL45
Chain: d
Length: 169 amino acids
Theoretical weight: 19.85 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q9BRJ2 (Residues: 117-285; Coverage: 55%)
Gene name: MRPL45
Pfam: Tim44-like domain
InterPro:
Large ribosomal subunit protein mL45 in PDB entry 7qh7, assembly 1, front view.
Large ribosomal subunit protein mL45 in PDB entry 7qh7, assembly 1, side view.
Large ribosomal subunit protein mL45 in PDB entry 7qh7, assembly 1, top view.
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Large ribosomal subunit protein mL48
Chain: f
Length: 17 amino acids
Theoretical weight: 2.02 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q96GC5 (Residues: 48-64; Coverage: 8%)
Gene names: CGI-118, HSPC290, MRPL48
Large ribosomal subunit protein mL48 in PDB entry 7qh7, assembly 1, front view.
Large ribosomal subunit protein mL48 in PDB entry 7qh7, assembly 1, side view.
Large ribosomal subunit protein mL48 in PDB entry 7qh7, assembly 1, top view.
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Large ribosomal subunit protein mL49
Chain: g
Length: 129 amino acids
Theoretical weight: 15.09 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q13405 (Residues: 38-166; Coverage: 78%)
Gene names: C11orf4, MRPL49, NOF1, OK/SW-cl.67
Pfam: Mitochondrial large subunit ribosomal protein (Img2)
InterPro: Large ribosomal subunit protein mL49
Large ribosomal subunit protein mL49 in PDB entry 7qh7, assembly 1, front view.
Large ribosomal subunit protein mL49 in PDB entry 7qh7, assembly 1, side view.
Large ribosomal subunit protein mL49 in PDB entry 7qh7, assembly 1, top view.
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Large ribosomal subunit protein mL50
Chain: h
Length: 105 amino acids
Theoretical weight: 12.11 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q8N5N7 (Residues: 53-157; Coverage: 67%)
Gene name: MRPL50
Pfam: Ribosomal subunit 39S
InterPro: Large ribosomal subunit protein mL50
Large ribosomal subunit protein mL50 in PDB entry 7qh7, assembly 1, front view.
Large ribosomal subunit protein mL50 in PDB entry 7qh7, assembly 1, side view.
Large ribosomal subunit protein mL50 in PDB entry 7qh7, assembly 1, top view.
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Large ribosomal subunit protein mL51
Chain: i
Length: 97 amino acids
Theoretical weight: 11.74 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q4U2R6 (Residues: 32-128; Coverage: 76%)
Gene names: CDA09, HSPC241, MRP64, MRPL51
Pfam: Mitochondrial ribosomal subunit
InterPro: Large ribosomal subunit protein mL51
Large ribosomal subunit protein mL51 in PDB entry 7qh7, assembly 1, front view.
Large ribosomal subunit protein mL51 in PDB entry 7qh7, assembly 1, side view.
Large ribosomal subunit protein mL51 in PDB entry 7qh7, assembly 1, top view.
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Large ribosomal subunit protein mL52
Chain: j
Length: 86 amino acids
Theoretical weight: 9.8 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q86TS9 (Residues: 23-108; Coverage: 70%)
Gene name: MRPL52
Pfam: Mitoribosomal protein mL52
InterPro: Large ribosomal subunit protein mL52
Large ribosomal subunit protein mL52 in PDB entry 7qh7, assembly 1, front view.
Large ribosomal subunit protein mL52 in PDB entry 7qh7, assembly 1, side view.
Large ribosomal subunit protein mL52 in PDB entry 7qh7, assembly 1, top view.
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Large ribosomal subunit protein mL63
Chain: o
Length: 81 amino acids
Theoretical weight: 9.77 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q9BQC6 (Residues: 22-102; Coverage: 79%)
Gene names: MRP63, MRPL57
Pfam: Mitochondrial ribosome protein 63
InterPro: Large ribosomal subunit protein mL63
Large ribosomal subunit protein mL63 in PDB entry 7qh7, assembly 1, front view.
Large ribosomal subunit protein mL63 in PDB entry 7qh7, assembly 1, side view.
Large ribosomal subunit protein mL63 in PDB entry 7qh7, assembly 1, top view.
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Large ribosomal subunit protein mL62
Chain: p
Length: 125 amino acids
Theoretical weight: 14.9 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q14197 (Residues: 38-193; Coverage: 61%)
Gene names: DS1, ICT1, MRPL58
Pfam: RF-1 domain
Large ribosomal subunit protein mL62 in PDB entry 7qh7, assembly 1, front view.
Large ribosomal subunit protein mL62 in PDB entry 7qh7, assembly 1, side view.
Large ribosomal subunit protein mL62 in PDB entry 7qh7, assembly 1, top view.
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Large ribosomal subunit protein mL64
Chain: q
Length: 101 amino acids
Theoretical weight: 11.94 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q8TAE8 (Residues: 25-125; Coverage: 46%)
Gene names: GADD45GIP1, MRPL59, PLINP1, PRG6
Pfam: Growth arrest and DNA-damage-inducible proteins-interacting protein 1
InterPro:
Large ribosomal subunit protein mL64 in PDB entry 7qh7, assembly 1, front view.
Large ribosomal subunit protein mL64 in PDB entry 7qh7, assembly 1, side view.
Large ribosomal subunit protein mL64 in PDB entry 7qh7, assembly 1, top view.
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Large ribosomal subunit protein mL66
Chain: r
Length: 140 amino acids
Theoretical weight: 16.35 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q9NVS2 (Residues: 57-196; Coverage: 71%)
Gene name: MRPS18A
Pfam: Ribosomal protein S18
InterPro:
Large ribosomal subunit protein mL66 in PDB entry 7qh7, assembly 1, front view.
Large ribosomal subunit protein mL66 in PDB entry 7qh7, assembly 1, side view.
Large ribosomal subunit protein mL66 in PDB entry 7qh7, assembly 1, top view.
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Large ribosomal subunit protein mL65
Chain: s
Length: 390 amino acids
Theoretical weight: 45.2 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q9NP92 (Residues: 41-430; Coverage: 89%)
Gene names: BM-047, MRPS30, PDCD9
Pfam: Mitochondrial 28S ribosomal protein S30 (PDCD9)
InterPro:
Large ribosomal subunit protein mL65 in PDB entry 7qh7, assembly 1, front view.
Large ribosomal subunit protein mL65 in PDB entry 7qh7, assembly 1, side view.
Large ribosomal subunit protein mL65 in PDB entry 7qh7, assembly 1, top view.
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Mitochondrial assembly of ribosomal large subunit protein 1
Chain: u
Length: 111 amino acids
Theoretical weight: 13.28 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q96EH3 (Residues: 91-201; Coverage: 47%)
Gene names: C7orf30, MALSU1
Pfam: Ribosomal silencing factor during starvation
InterPro:
Mitochondrial assembly of ribosomal large subunit protein 1 in PDB entry 7qh7, assembly 1, front view.
Mitochondrial assembly of ribosomal large subunit protein 1 in PDB entry 7qh7, assembly 1, side view.
Mitochondrial assembly of ribosomal large subunit protein 1 in PDB entry 7qh7, assembly 1, top view.
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Mitochondrial ribosome and complex I assembly factor AltMIEF1
Chain: v
Length: 69 amino acids
Theoretical weight: 8.33 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: L0R8F8 (Residues: 2-70; Coverage: 99%)
Gene names: AltMIEF1, AltMiD51, MIEF1
Pfam: Complex 1 protein (LYR family)
InterPro:
Mitochondrial ribosome and complex I assembly factor AltMIEF1 in PDB entry 7qh7, assembly 1, front view.
Mitochondrial ribosome and complex I assembly factor AltMIEF1 in PDB entry 7qh7, assembly 1, side view.
Mitochondrial ribosome and complex I assembly factor AltMIEF1 in PDB entry 7qh7, assembly 1, top view.
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Acyl carrier protein, mitochondrial
Chain: w
Length: 79 amino acids
Theoretical weight: 9.14 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: O14561 (Residues: 74-152; Coverage: 51%)
Gene name: NDUFAB1
Pfam: Phosphopantetheine attachment site
InterPro:
Acyl carrier protein, mitochondrial in PDB entry 7qh7, assembly 1, front view.
Acyl carrier protein, mitochondrial in PDB entry 7qh7, assembly 1, side view.
Acyl carrier protein, mitochondrial in PDB entry 7qh7, assembly 1, top view.
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Large ribosomal subunit protein bL36m
Chain: 4
Length: 37 amino acids
Theoretical weight: 4.77 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q9P0J6 (Residues: 66-102; Coverage: 36%)
Gene names: BRIP1, MRPL36
Pfam: Ribosomal protein L36
InterPro:
Large ribosomal subunit protein bL36m in PDB entry 7qh7, assembly 1, front view.
Large ribosomal subunit protein bL36m in PDB entry 7qh7, assembly 1, side view.
Large ribosomal subunit protein bL36m in PDB entry 7qh7, assembly 1, top view.
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RNA chain A
Name: 16S ribosomal RNA
Representative chains: A
Length: 1256 nucleotides
Theoretical weight: 403.06 KDa
Rfam: Bacterial large subunit ribosomal RNA
16S ribosomal RNA in PDB entry 7qh7, assembly 1, front view.
16S ribosomal RNA in PDB entry 7qh7, assembly 1, side view.
16S ribosomal RNA in PDB entry 7qh7, assembly 1, top view.
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RNA chain B
Name: mitochondrial tRNAVal
Representative chains: B
Length: 61 nucleotides
Theoretical weight: 19.53 KDa
mitochondrial tRNAVal in PDB entry 7qh7, assembly 1, front view.
mitochondrial tRNAVal in PDB entry 7qh7, assembly 1, side view.
mitochondrial tRNAVal in PDB entry 7qh7, assembly 1, top view.
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