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In vitro assembled 258-391 tau filaments with heparan sulfate, 700 rpm (40a)

Electron Microscopy
2.27Å resolution
PDB entry 7qk6 coloured by chain, front view.
PDB entry 7qk6 coloured by chain, side view.
PDB entry 7qk6 coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
homo trimer (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Microtubule-associated protein tau
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Multimeric state: homo trimer
Accessible surface area: 9514.34 Å2
Buried surface area: 8519.3 Å2
Dissociation area: 4,259.65 Å2
Dissociation energy (ΔGdiss): 63.43 kcal/mol
Dissociation entropy (TΔSdiss): 22.63 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-145400

Macromolecules

Microtubule-associated protein tau
Chains: A, B, C
Length: 441 amino acids
Theoretical weight: 45.92 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P10636 (Residues: 1-758; Coverage: 58%)
  • Best match: P10636-8 (Residues: 1-441)
Gene names: MAPT, MAPTL, MTBT1, TAU
Pfam: Tau and MAP protein, tubulin-binding repeat
InterPro:
Microtubule-associated protein tau in PDB entry 7qk6, assembly 1, front view.
Microtubule-associated protein tau in PDB entry 7qk6, assembly 1, side view.
Microtubule-associated protein tau in PDB entry 7qk6, assembly 1, top view.
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