7r5v

Electron Microscopy
4.55Å resolution

Structure of the human CCAN CENP-A alpha-satellite complex

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero tridecamer (preferred)
PDBe Complex ID:
PDB-CPX-121884 (preferred)
Entry contents:
11 distinct polypeptide molecules
2 distinct DNA molecules
Macromolecules (13 distinct):
Centromere protein H Chain: H
Molecule details ›
Chain: H
Length: 247 amino acids
Theoretical weight: 28.52 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
  • Canonical: Q9H3R5 (Residues: 1-247; Coverage: 100%)
Gene names: CENPH, ICEN35
Sequence domains: Centromere protein H (CENP-H)
Centromere protein I Chain: I
Molecule details ›
Chain: I
Length: 756 amino acids
Theoretical weight: 86.82 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
  • Canonical: Q92674 (Residues: 1-756; Coverage: 100%)
Gene names: CENPI, FSHPRH1, ICEN19, LRPR1
Sequence domains: Mis6
Centromere protein K Chain: K
Centromere protein L Chain: L
Centromere protein M Chain: M
Centromere protein N Chain: N
Centromere protein O Chain: O
Centromere protein P Chain: P
Centromere protein Q Chain: Q
Centromere protein U Chain: U
Centromere protein R Chain: R
DNA (171-MER) Chain: J
DNA (171-MER) Chain: i

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 4.55Å
Relevant EMDB volumes: EMD-14341
Expression system: Trichoplusia ni