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Structure of PfCSP peptide 21 with antibody iGL-CIS43.D3

X-ray diffraction
3Å resolution
PDB entry 7raj coloured by chain, front view.
PDB entry 7raj coloured by chain, side view.
PDB entry 7raj coloured by chain, top view.
Source organisms:
Assembly composition:
hetero trimer (preferred)
Entry contents: 3 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Circumsporozoite protein and IG-heavy chain and IG-light kappa chain
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Multimeric state: hetero trimer
Accessible surface area: 19318.53 Å2
Buried surface area: 5889.83 Å2
Dissociation area: 761.8 Å2
Dissociation energy (ΔGdiss): 3.66 kcal/mol
Dissociation entropy (TΔSdiss): 7.77 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-279477

Macromolecules

iGL-CIS43.D3 Fab Heavy chain
Chain: H
Length: 226 amino acids
Theoretical weight: 24.25 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
InterPro:
iGL-CIS43.D3 Fab Heavy chain in PDB entry 7raj, assembly 1, front view.
iGL-CIS43.D3 Fab Heavy chain in PDB entry 7raj, assembly 1, side view.
iGL-CIS43.D3 Fab Heavy chain in PDB entry 7raj, assembly 1, top view.
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iGL-CIS43.D3 Fab light chain
Chain: L
Length: 220 amino acids
Theoretical weight: 24.25 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
InterPro:
iGL-CIS43.D3 Fab light chain in PDB entry 7raj, assembly 1, front view.
iGL-CIS43.D3 Fab light chain in PDB entry 7raj, assembly 1, side view.
iGL-CIS43.D3 Fab light chain in PDB entry 7raj, assembly 1, top view.
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Circumsporozoite protein
Chain: A
Length: 15 amino acids
Theoretical weight: 1.56 KDa
Source organism: Plasmodium falciparum
Expression system: Not provided
UniProt:
  • Canonical: P02893 (Residues: 120-134; Coverage: 4%)
Gene name: CSP
ASN-PRO-ASP-PRO-ASN-ALA-ASN-PRO-ASN-VAL-ASP-PRO-ASN-ALA-ASN in PDB entry 7raj, assembly 1, front view.
ASN-PRO-ASP-PRO-ASN-ALA-ASN-PRO-ASN-VAL-ASP-PRO-ASN-ALA-ASN in PDB entry 7raj, assembly 1, side view.
ASN-PRO-ASP-PRO-ASN-ALA-ASN-PRO-ASN-VAL-ASP-PRO-ASN-ALA-ASN in PDB entry 7raj, assembly 1, top view.
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