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Crystal structure of PCDN-16B, an anti-HIV antibody from the PCDN bnAb lineage (non-cysteinylated state)

X-ray diffraction
1.93Å resolution
PDB entry 7rdj coloured by chain, front view.
PDB entry 7rdj coloured by chain, side view.
PDB entry 7rdj coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
hetero dimer (preferred)
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: IG-heavy chain and IG-light kappa chain
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Multimeric state: hetero dimer
Accessible surface area: 20756.27 Å2
Buried surface area: 4828.93 Å2
Dissociation area: 1,957.04 Å2
Dissociation energy (ΔGdiss): 9.51 kcal/mol
Dissociation entropy (TΔSdiss): 13.24 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-214433

Macromolecules

PCDN-16B Fab light chain
Chain: A
Length: 216 amino acids
Theoretical weight: 23.46 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
InterPro:
PCDN-16B Fab light chain in PDB entry 7rdj, assembly 1, front view.
PCDN-16B Fab light chain in PDB entry 7rdj, assembly 1, side view.
PCDN-16B Fab light chain in PDB entry 7rdj, assembly 1, top view.
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PCDN-16B Fab heavy chain
Chain: B
Length: 232 amino acids
Theoretical weight: 24.82 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
InterPro:
PCDN-16B Fab heavy chain in PDB entry 7rdj, assembly 1, front view.
PCDN-16B Fab heavy chain in PDB entry 7rdj, assembly 1, side view.
PCDN-16B Fab heavy chain in PDB entry 7rdj, assembly 1, top view.
Molecule details ›

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