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Mycobacterial CIII2CIV2 supercomplex, Telacebec (Q203) bound

Electron Microscopy
3Å resolution
PDB entry 7rh7 coloured by chain, front view.
PDB entry 7rh7 coloured by chain, side view.
PDB entry 7rh7 coloured by chain, top view.
Source organism: Mycolicibacterium smegmatis MC2 155
Assembly composition:
hetero 24-mer (preferred)
Entry contents: 12 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Multimeric state: hetero 24-mer
Accessible surface area: 176542.42 Å2
Buried surface area: 231692.46 Å2
Dissociation area: 15.32 Å2
Dissociation energy (ΔGdiss): -0.7 kcal/mol
Dissociation entropy (TΔSdiss): 2.1 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-106256

Macromolecules

LpqE protein
Chains: W, c
Length: 159 amino acids
Theoretical weight: 16.41 KDa
Source organism: Mycolicibacterium smegmatis MC2 155
UniProt:
  • Canonical: A0R562 (Residues: 24-182; Coverage: 98%)
Gene name: MSMEG_6078
LpqE protein in PDB entry 7rh7, assembly 1, front view.
LpqE protein in PDB entry 7rh7, assembly 1, side view.
LpqE protein in PDB entry 7rh7, assembly 1, top view.
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cytochrome-c oxidase
Chains: K, Q
Length: 312 amino acids
Theoretical weight: 35.2 KDa
Source organism: Mycolicibacterium smegmatis MC2 155
UniProt:
  • Canonical: A0R057 (Residues: 27-338; Coverage: 92%)
Gene name: MSMEG_4268
Pfam: Cytochrome C oxidase subunit II, periplasmic domain
InterPro:
cytochrome-c oxidase in PDB entry 7rh7, assembly 1, front view.
cytochrome-c oxidase in PDB entry 7rh7, assembly 1, side view.
cytochrome-c oxidase in PDB entry 7rh7, assembly 1, top view.
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Cytochrome c oxidase subunit 1
Chains: L, R
Length: 552 amino acids
Theoretical weight: 61.73 KDa
Source organism: Mycolicibacterium smegmatis MC2 155
InterPro:
Cytochrome c oxidase subunit 1 in PDB entry 7rh7, assembly 1, front view.
Cytochrome c oxidase subunit 1 in PDB entry 7rh7, assembly 1, side view.
Cytochrome c oxidase subunit 1 in PDB entry 7rh7, assembly 1, top view.
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Probable cytochrome c oxidase subunit 3
Chains: S, X
Length: 203 amino acids
Theoretical weight: 22.2 KDa
Source organism: Mycolicibacterium smegmatis MC2 155
UniProt:
  • Canonical: A0R049 (Residues: 1-203; Coverage: 100%)
Gene name: MSMEG_4260
Pfam: Cytochrome c oxidase subunit III
InterPro:
Probable cytochrome c oxidase subunit 3 in PDB entry 7rh7, assembly 1, front view.
Probable cytochrome c oxidase subunit 3 in PDB entry 7rh7, assembly 1, side view.
Probable cytochrome c oxidase subunit 3 in PDB entry 7rh7, assembly 1, top view.
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Cytochrome c oxidase polypeptide 4
Chains: T, Z
Length: 139 amino acids
Theoretical weight: 15.18 KDa
Source organism: Mycolicibacterium smegmatis MC2 155
UniProt:
  • Canonical: A0R056 (Residues: 1-139; Coverage: 100%)
Gene name: MSMEG_4267
Pfam: Cytochrome c oxidase subunit IV
InterPro: Cytochrome c oxidase subunit IV, actinobacteria
Cytochrome c oxidase polypeptide 4 in PDB entry 7rh7, assembly 1, front view.
Cytochrome c oxidase polypeptide 4 in PDB entry 7rh7, assembly 1, side view.
Cytochrome c oxidase polypeptide 4 in PDB entry 7rh7, assembly 1, top view.
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Cytochrome c oxidase subunit CtaJ
Chains: U, a
Length: 79 amino acids
Theoretical weight: 8.37 KDa
Source organism: Mycolicibacterium smegmatis MC2 155
UniProt:
  • Canonical: A0R1B6 (Residues: 1-79; Coverage: 100%)
Gene name: MSMEG_4693
Cytochrome c oxidase subunit CtaJ in PDB entry 7rh7, assembly 1, front view.
Cytochrome c oxidase subunit CtaJ in PDB entry 7rh7, assembly 1, side view.
Cytochrome c oxidase subunit CtaJ in PDB entry 7rh7, assembly 1, top view.
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Uncharacterized protein MSMEG_4692/MSMEI_4575
Chains: V, b
Length: 145 amino acids
Theoretical weight: 14.81 KDa
Source organism: Mycolicibacterium smegmatis MC2 155
UniProt:
  • Canonical: A0R1B5 (Residues: 13-157; Coverage: 92%)
Gene names: MSMEG_4692, MSMEI_4575
Pfam: Domain of unknown function (DUF5130)
InterPro: Protein of unknown function DUF5130
Uncharacterized protein MSMEG_4692/MSMEI_4575 in PDB entry 7rh7, assembly 1, front view.
Uncharacterized protein MSMEG_4692/MSMEI_4575 in PDB entry 7rh7, assembly 1, side view.
Uncharacterized protein MSMEG_4692/MSMEI_4575 in PDB entry 7rh7, assembly 1, top view.
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Transmembrane protein
Chains: J, P
Length: 100 amino acids
Theoretical weight: 11.33 KDa
Source organism: Mycolicibacterium smegmatis MC2 155
UniProt:
  • Canonical: A0QVH4 (Residues: 2-84; Coverage: 99%)
Gene name: MSMEG_2575
Pfam: Protein of unknown function (DUF2631)
InterPro: Protein of unknown function DUF2631
Transmembrane protein in PDB entry 7rh7, assembly 1, front view.
Transmembrane protein in PDB entry 7rh7, assembly 1, side view.
Transmembrane protein in PDB entry 7rh7, assembly 1, top view.
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Superoxide dismutase [Cu-Zn]
Chains: D, G
Length: 216 amino acids
Theoretical weight: 21.22 KDa
Source organism: Mycolicibacterium smegmatis MC2 155
UniProt:
  • Canonical: A0QQQ1 (Residues: 21-236; Coverage: 100%)
Gene names: MSMEG_0835, sodC
Pfam: Copper/zinc superoxide dismutase (SODC)
InterPro:
Superoxide dismutase [Cu-Zn] in PDB entry 7rh7, assembly 1, front view.
Superoxide dismutase [Cu-Zn] in PDB entry 7rh7, assembly 1, side view.
Superoxide dismutase [Cu-Zn] in PDB entry 7rh7, assembly 1, top view.
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Cytochrome bc1 complex cytochrome c subunit
Chains: I, O
Length: 223 amino acids
Theoretical weight: 23.18 KDa
Source organism: Mycolicibacterium smegmatis MC2 155
UniProt:
  • Canonical: I7FPH1 (Residues: 72-294; Coverage: 76%)
Gene names: MSMEI_4161, qcrC
Pfam:
InterPro:
Cytochrome bc1 complex cytochrome c subunit in PDB entry 7rh7, assembly 1, front view.
Cytochrome bc1 complex cytochrome c subunit in PDB entry 7rh7, assembly 1, side view.
Cytochrome bc1 complex cytochrome c subunit in PDB entry 7rh7, assembly 1, top view.
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Cytochrome bc1 complex cytochrome b subunit
Chains: E, F
Length: 535 amino acids
Theoretical weight: 59.11 KDa
Source organism: Mycolicibacterium smegmatis MC2 155
UniProt:
  • Canonical: A0R052 (Residues: 4-538; Coverage: 98%)
Gene name: MSMEG_4263
Pfam: Cytochrome b(N-terminal)/b6/petB
InterPro:
Cytochrome bc1 complex cytochrome b subunit in PDB entry 7rh7, assembly 1, front view.
Cytochrome bc1 complex cytochrome b subunit in PDB entry 7rh7, assembly 1, side view.
Cytochrome bc1 complex cytochrome b subunit in PDB entry 7rh7, assembly 1, top view.
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Cytochrome bc1 complex Rieske iron-sulfur subunit
Chains: M, Y
Length: 382 amino acids
Theoretical weight: 42.21 KDa
Source organism: Mycolicibacterium smegmatis MC2 155
UniProt:
  • Canonical: I7GD61 (Residues: 40-421; Coverage: 91%)
Gene names: MSMEI_4162, qcrA
Pfam:
InterPro:
Cytochrome bc1 complex Rieske iron-sulfur subunit in PDB entry 7rh7, assembly 1, front view.
Cytochrome bc1 complex Rieske iron-sulfur subunit in PDB entry 7rh7, assembly 1, side view.
Cytochrome bc1 complex Rieske iron-sulfur subunit in PDB entry 7rh7, assembly 1, top view.
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