Structure analysis

Crystal Structure of the ER-alpha Ligand-binding Domain (L372S, L536S) in complex with DMERI-25

X-ray diffraction
1.7Å resolution
Source organism: Homo sapiens
Assembly composition:
homo dimer (preferred)
Entry contents: 1 distinct polypeptide molecule

Assemblies

Assembly 1 (preferred)
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Multimeric state: homo dimer
Accessible surface area: 19576.7 Å2
Buried surface area: 3184.83 Å2
Dissociation area: 1,592.42 Å2
Dissociation energy (ΔGdiss): 10.8 kcal/mol
Dissociation entropy (TΔSdiss): 13.32 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-136919
Assembly 2
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Multimeric state: homo dimer
Accessible surface area: 19232.5 Å2
Buried surface area: 3211.9 Å2
Dissociation area: 1,605.95 Å2
Dissociation energy (ΔGdiss): 10.56 kcal/mol
Dissociation entropy (TΔSdiss): 13.29 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-136919

Macromolecules

Chains: A, B, C, D
Length: 257 amino acids
Theoretical weight: 29.44 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P03372 (Residues: 298-554; Coverage: 43%)
Gene names: ESR, ESR1, NR3A1
Pfam: Ligand-binding domain of nuclear hormone receptor
InterPro:
PDBe-KB: UniProt Coverage View: P03372  
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