› 7rsl

Electron Microscopy
3.45Å resolution

Seipin forms a flexible cage at lipid droplet formation sites

Released:
DOI: 10.2210/pdb7rsl/pdb
PDB entry 7rsl coloured by chain, front view.
PDB entry 7rsl coloured by chain, side view.
PDB entry 7rsl coloured by chain, top view.
Source organism: Saccharomyces cerevisiae
Primary publication:
Seipin forms a flexible cage at lipid droplet formation sites.
Arlt H, Sui X, Folger B, Adams C, Chen X, Remme R, Hamprecht FA, DiMaio F, Liao M, Goodman JM, Farese RV, Walther TC
Nat Struct Mol Biol 29 194-202 (2022)
PMID: 35210614
Related structures: EMD-24674

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
homo decamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-170280 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Seipin Chains: A, B, C, D, E, F, G, H, I, J
Molecule details ›
Chains: A, B, C, D, E, F, G, H, I, J
Length: 285 amino acids
Theoretical weight: 32.62 KDa
Source organism: Saccharomyces cerevisiae
Expression system: Saccharomyces cerevisiae
UniProt:
  • Canonical: Q06058 (Residues: 1-285; Coverage: 100%)
Gene names: FLD1, SEI1, YLR404W

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.45Å
Relevant EMDB volumes: EMD-24674
Expression system: Saccharomyces cerevisiae

Quick links

Citations

11 review citations

Lipid droplet biogenesis and functions in health and disease.
Zadoorian et al. (2023)
10 more

2 mentions without citation

Structure and function of lipid droplet assembly complexes.
Walther et al. (2023)
1 more