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Seipin forms a flexible cage at lipid droplet formation sites

Electron Microscopy
3.45Å resolution
PDB entry 7rsl coloured by chain, front view.
PDB entry 7rsl coloured by chain, side view.
PDB entry 7rsl coloured by chain, top view.
Source organism: Saccharomyces cerevisiae
Assembly composition:
homo decamer (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Seipin
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Multimeric state: homo decamer
Accessible surface area: 114108.19 Å2
Buried surface area: 28308.47 Å2
Dissociation area: 5,925.89 Å2
Dissociation energy (ΔGdiss): 8.24 kcal/mol
Dissociation entropy (TΔSdiss): 61.55 kcal/mol
Symmetry number: 5
PDBe Complex ID: PDB-CPX-170280

Macromolecules

Seipin
Chains: A, B, C, D, E, F, G, H, I, J
Length: 285 amino acids
Theoretical weight: 32.62 KDa
Source organism: Saccharomyces cerevisiae
Expression system: Saccharomyces cerevisiae
UniProt:
  • Canonical: Q06058 (Residues: 1-285; Coverage: 100%)
Gene names: FLD1, SEI1, YLR404W
Seipin in PDB entry 7rsl, assembly 1, front view.
Seipin in PDB entry 7rsl, assembly 1, side view.
Seipin in PDB entry 7rsl, assembly 1, top view.
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