› › Structure analysis

Crystal structure of human hypoxanthine guanine phosphoribzosyltransferase in complex with (4S,7S)-7-hydroxy-4-((guanin-9-yl)methyl)-2,5-dioxaheptan-1,7-diphosphonate

X-ray diffraction
2.582Å resolution
PDB entry 7san coloured by chain, front view.
PDB entry 7san coloured by chain, side view.
PDB entry 7san coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
homo tetramer (preferred)
Entry contents: 1 distinct polypeptide molecule

Quick links

Assemblies

Assembly 1 (preferred)
Download    3D Visualisation
Assembly Name: Hypoxanthine-guanine phosphoribosyltransferase
hide full assembly name
Multimeric state: homo tetramer
Accessible surface area: 32948.09 Å2
Buried surface area: 9211.17 Å2
Dissociation area: 1,678.95 Å2
Dissociation energy (ΔGdiss): 7.53 kcal/mol
Dissociation entropy (TΔSdiss): 14.09 kcal/mol
Symmetry number: 4
PDBe Complex ID: PDB-CPX-132564

Macromolecules

Hypoxanthine-guanine phosphoribosyltransferase
Chains: A, B, C, D
Length: 217 amino acids
Theoretical weight: 24.39 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P00492 (Residues: 2-218; Coverage: 100%)
Gene names: HPRT, HPRT1
Pfam: Phosphoribosyl transferase domain
InterPro:
Hypoxanthine-guanine phosphoribosyltransferase in PDB entry 7san, assembly 1, front view.
Hypoxanthine-guanine phosphoribosyltransferase in PDB entry 7san, assembly 1, side view.
Hypoxanthine-guanine phosphoribosyltransferase in PDB entry 7san, assembly 1, top view.
Molecule details ›

Search similar proteins

Quick links