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Crystal structure of T. brucei hypoxanthine guanine phosphoribosyltransferase in complex with (4S,7S)-7-hydroxy-4-((guanin-9-yl)methyl)-2,5-dioxaheptan-1,7-diphosphonate

X-ray diffraction
2.647Å resolution
PDB entry 7sb7 coloured by chain, front view.
PDB entry 7sb7 coloured by chain, side view.
PDB entry 7sb7 coloured by chain, top view.
Source organism: Trypanosoma brucei brucei
Assembly composition:
homo dimer (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Hypoxanthine-guanine phosphoribosyltransferase
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Multimeric state: homo dimer
Accessible surface area: 15676.66 Å2
Buried surface area: 3002.57 Å2
Dissociation area: 1,501.29 Å2
Dissociation energy (ΔGdiss): 4.48 kcal/mol
Dissociation entropy (TΔSdiss): 12.75 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-170435

Macromolecules

Hypoxanthine-guanine phosphoribosyltransferase
Chains: A, B
Length: 216 amino acids
Theoretical weight: 24.22 KDa
Source organism: Trypanosoma brucei brucei
Expression system: Escherichia coli
UniProt:
  • Canonical: Q07010 (Residues: 1-210; Coverage: 100%)
Gene name: HGPRT
Pfam: Phosphoribosyl transferase domain
InterPro:
Hypoxanthine-guanine phosphoribosyltransferase in PDB entry 7sb7, assembly 1, front view.
Hypoxanthine-guanine phosphoribosyltransferase in PDB entry 7sb7, assembly 1, side view.
Hypoxanthine-guanine phosphoribosyltransferase in PDB entry 7sb7, assembly 1, top view.
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