PDB 7scr biological assemblies and structure analysis ‹ Protein Data Bank in Europe (PDBe)

Assemblies

Assembly 1 (preferred)

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Assembly Name: Phosphoribosyltransferase domain-containing protein
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Multimeric state: homo dimer

Accessible surface area: 17810.04 Å²

Buried surface area: 4160.76 Å²

Dissociation area: 2,080.38 Å²

Dissociation energy (ΔG^diss): 3.49 kcal/mol

Dissociation entropy (TΔS^diss): 13.32 kcal/mol

Symmetry number: 2

PDBe Complex ID: PDB-CPX-174408

$Homo dimeric assembly 1 of PDB entry 7scr coloured by chemically distinct molecules, front view. This structure contains: <ul class='image_legend_ul'><li class='image_legend_li'>2 copies of Phosphoribosyltransferase domain-containing protein;</li> <li class='image_legend_li'>2 copies of ({(2S)-3-(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)-2-[(2S)-2-hydroxy-2-phosphonoethoxy]propoxy}methyl)phosphonic acid;</li> <li class='image_legend_li'>1 copy of water.</li></ul>}$

$Homo dimeric assembly 1 of PDB entry 7scr coloured by chemically distinct molecules, side view. This structure contains: <ul class='image_legend_ul'><li class='image_legend_li'>2 copies of Phosphoribosyltransferase domain-containing protein;</li> <li class='image_legend_li'>2 copies of ({(2S)-3-(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)-2-[(2S)-2-hydroxy-2-phosphonoethoxy]propoxy}methyl)phosphonic acid;</li> <li class='image_legend_li'>1 copy of water.</li></ul>}$

$Homo dimeric assembly 1 of PDB entry 7scr coloured by chemically distinct molecules, top view. This structure contains: <ul class='image_legend_ul'><li class='image_legend_li'>2 copies of Phosphoribosyltransferase domain-containing protein;</li> <li class='image_legend_li'>2 copies of ({(2S)-3-(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)-2-[(2S)-2-hydroxy-2-phosphonoethoxy]propoxy}methyl)phosphonic acid;</li> <li class='image_legend_li'>1 copy of water.</li></ul>}$

Assembly 2

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Assembly Name: Phosphoribosyltransferase domain-containing protein
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Multimeric state: homo dimer

Accessible surface area: 18042.99 Å²

Buried surface area: 4040.31 Å²

Dissociation area: 2,020.16 Å²

Dissociation energy (ΔG^diss): 5.66 kcal/mol

Dissociation entropy (TΔS^diss): 13.29 kcal/mol

Symmetry number: 2

PDBe Complex ID: PDB-CPX-174408

$Homo dimeric assembly 2 of PDB entry 7scr coloured by chemically distinct molecules, front view. This structure contains: <ul class='image_legend_ul'><li class='image_legend_li'>2 copies of Phosphoribosyltransferase domain-containing protein;</li> <li class='image_legend_li'>2 copies of ({(2S)-3-(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)-2-[(2S)-2-hydroxy-2-phosphonoethoxy]propoxy}methyl)phosphonic acid;</li> <li class='image_legend_li'>1 copy of water.</li></ul>}$

$Homo dimeric assembly 2 of PDB entry 7scr coloured by chemically distinct molecules, side view. This structure contains: <ul class='image_legend_ul'><li class='image_legend_li'>2 copies of Phosphoribosyltransferase domain-containing protein;</li> <li class='image_legend_li'>2 copies of ({(2S)-3-(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)-2-[(2S)-2-hydroxy-2-phosphonoethoxy]propoxy}methyl)phosphonic acid;</li> <li class='image_legend_li'>1 copy of water.</li></ul>}$

$Homo dimeric assembly 2 of PDB entry 7scr coloured by chemically distinct molecules, top view. This structure contains: <ul class='image_legend_ul'><li class='image_legend_li'>2 copies of Phosphoribosyltransferase domain-containing protein;</li> <li class='image_legend_li'>2 copies of ({(2S)-3-(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)-2-[(2S)-2-hydroxy-2-phosphonoethoxy]propoxy}methyl)phosphonic acid;</li> <li class='image_legend_li'>1 copy of water.</li></ul>}$

Assembly 3

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Assembly Name: Phosphoribosyltransferase domain-containing protein
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Multimeric state: homo dimer

Accessible surface area: 18013.89 Å²

Buried surface area: 4174.16 Å²

Dissociation area: 2,087.08 Å²

Dissociation energy (ΔG^diss): 1.83 kcal/mol

Dissociation entropy (TΔS^diss): 13.32 kcal/mol

Symmetry number: 2

PDBe Complex ID: PDB-CPX-174408

$Homo dimeric assembly 3 of PDB entry 7scr coloured by chemically distinct molecules, front view. This structure contains: <ul class='image_legend_ul'><li class='image_legend_li'>2 copies of Phosphoribosyltransferase domain-containing protein;</li> <li class='image_legend_li'>2 copies of ({(2S)-3-(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)-2-[(2S)-2-hydroxy-2-phosphonoethoxy]propoxy}methyl)phosphonic acid;</li> <li class='image_legend_li'>1 copy of water.</li></ul>}$

$Homo dimeric assembly 3 of PDB entry 7scr coloured by chemically distinct molecules, side view. This structure contains: <ul class='image_legend_ul'><li class='image_legend_li'>2 copies of Phosphoribosyltransferase domain-containing protein;</li> <li class='image_legend_li'>2 copies of ({(2S)-3-(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)-2-[(2S)-2-hydroxy-2-phosphonoethoxy]propoxy}methyl)phosphonic acid;</li> <li class='image_legend_li'>1 copy of water.</li></ul>}$

$Homo dimeric assembly 3 of PDB entry 7scr coloured by chemically distinct molecules, top view. This structure contains: <ul class='image_legend_ul'><li class='image_legend_li'>2 copies of Phosphoribosyltransferase domain-containing protein;</li> <li class='image_legend_li'>2 copies of ({(2S)-3-(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)-2-[(2S)-2-hydroxy-2-phosphonoethoxy]propoxy}methyl)phosphonic acid;</li> <li class='image_legend_li'>1 copy of water.</li></ul>}$

Macromolecules

Phosphoribosyltransferase domain-containing protein

Chains: A, B, C, D, E, F
Length: 272 amino acids
Theoretical weight: 30.59 KDa
Source organism: Trypanosoma brucei brucei
Expression system: Escherichia coli
UniProt:

Canonical: Q38CA1 (Residues: 2-234; Coverage: 100%)

Gene name: Tb10.70.6660
Pfam: Phosphoribosyl transferase domain
InterPro:

Phosphoribosyltransferase-like
Phosphoribosyltransferase domain

Phosphoribosyltransferase domain-containing protein in PDB entry 7scr, assembly 1, front view.

Phosphoribosyltransferase domain-containing protein in PDB entry 7scr, assembly 1, side view.

Phosphoribosyltransferase domain-containing protein in PDB entry 7scr, assembly 1, top view.

FASTA Sequence


    >pdb|7scr|A B C D E F

MGSSHHHHHHDYDIPTTENLYFQGHMASMTGGQQMGRGSHSGHPLKPNVVGRDADGNVTVDGRSYPMAESVVATESTIHRSMKEMAQTLANAYKTLKHRDTHNKGNSALAPITDENPLIIISVLKGSYIFTADMVRYLGDCGLPNVVDFIRITSYRGTTKSSGTVQVLDNLRFTELTGKHVLIMEDIADTGRTMKLLVEKIRREYRPASLKVCVLVDKPGGRVVDFKPEFVCLTAPTRYVVGYGFEVNDRYRNYRHVFVLKPEYAKRYPSKL

PDBe-KB: UniProt Coverage View: Q38CA1

Molecule details ›

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FASTA (Protein chains A, B, C, D, E, F)
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Structure Factors
SIFTS XML file with residue-level mappings

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Similar 3D structures (PDBeFold)
Similar sequences

BLAST Q38CA1 (UniProt)

Protein Data Bank in Europe

Crystal structure of trypanosome brucei hypoxanthine-guanine-xanthine phosphoribzosyltransferase in complex with (4S,7S)-7-hydroxy-4-((guanin-9-yl)methyl)-2,5-dioxaheptan-1,7-diphosphonate

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Assemblies

Assembly 1 (preferred)

Assembly 2

Assembly 3

Macromolecules

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PDBe › 7scr › Structure analysis

Crystal structure of trypanosome brucei hypoxanthine-guanine-xanthine phosphoribzosyltransferase in complex with (4S,7S)-7-hydroxy-4-((guanin-9-yl)methyl)-2,5-dioxaheptan-1,7-diphosphonate

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Assemblies

Assembly 1 (preferred)

Assembly 2

Assembly 3

Macromolecules

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7scr › Structure analysis