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Crystal structure of human Fibrillarin in complex with fragment 1 from cocktail soak

X-ray diffraction
1.75Å resolution
PDB entry 7se8 coloured by chain, front view.
PDB entry 7se8 coloured by chain, side view.
PDB entry 7se8 coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1
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Assembly Name: rRNA 2'-O-methyltransferase fibrillarin
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Multimeric state: monomeric
Accessible surface area: 11043.22 Å2
Buried surface area: 1043.96 Å2
Dissociation area: 110.49 Å2
Dissociation energy (ΔGdiss): -2.61 kcal/mol
Dissociation entropy (TΔSdiss): 0.39 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-149520
Assembly 2 (preferred)
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Assembly Name: rRNA 2'-O-methyltransferase fibrillarin
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Multimeric state: monomeric
Accessible surface area: 10767.59 Å2
Buried surface area: 755.86 Å2
Dissociation area: 109.92 Å2
Dissociation energy (ΔGdiss): -2.6 kcal/mol
Dissociation entropy (TΔSdiss): 0.4 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-149520

Macromolecules

rRNA 2'-O-methyltransferase fibrillarin
Chains: A, B
Length: 242 amino acids
Theoretical weight: 26.68 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P22087 (Residues: 83-321; Coverage: 75%)
Gene names: FBL, FIB1, FLRN
Pfam: Fibrillarin
InterPro:
rRNA 2'-O-methyltransferase fibrillarin in PDB entry 7se8, assembly 2, front view.
rRNA 2'-O-methyltransferase fibrillarin in PDB entry 7se8, assembly 2, side view.
rRNA 2'-O-methyltransferase fibrillarin in PDB entry 7se8, assembly 2, top view.
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