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Papain-Like Protease of SARS CoV-2, C111S mutant, in complex with PLP_Snyder608 inhibitor

X-ray diffraction
1.79Å resolution
PDB entry 7sgu coloured by chain, front view.
PDB entry 7sgu coloured by chain, side view.
PDB entry 7sgu coloured by chain, top view.
Source organism: Severe acute respiratory syndrome coronavirus 2
Assembly composition:
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: 3C-like proteinase nsp5
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Multimeric state: monomeric
Accessible surface area: 15524.32 Å2
Buried surface area: 632.17 Å2
Dissociation area: 86.45 Å2
Dissociation energy (ΔGdiss): 1.22 kcal/mol
Dissociation entropy (TΔSdiss): -1.31 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-145022

Macromolecules

Papain-like protease nsp3
Chain: A
Length: 318 amino acids
Theoretical weight: 35.93 KDa
Source organism: Severe acute respiratory syndrome coronavirus 2
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P0DTD1 (Residues: 1564-1878; Coverage: 4%)
Gene names: 1a-1b, rep
Pfam: Coronavirus papain-like peptidase
InterPro:
Papain-like protease nsp3 in PDB entry 7sgu, assembly 1, front view.
Papain-like protease nsp3 in PDB entry 7sgu, assembly 1, side view.
Papain-like protease nsp3 in PDB entry 7sgu, assembly 1, top view.
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