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CRYSTAL STRUCTURE OF ENDOPLASMIC RETICULUM AMINOPEPTIDASE 2 (ERAP2) COMPLEX WITH A HIGHLY SELECTIVE AND POTENT SMALL MOLECULE

X-ray diffraction
3.2Å resolution
PDB entry 7sh0 coloured by chain, front view.
PDB entry 7sh0 coloured by chain, side view.
PDB entry 7sh0 coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Endoplasmic reticulum aminopeptidase 2
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Multimeric state: monomeric
Accessible surface area: 36523.66 Å2
Buried surface area: 571.34 Å2
Dissociation area: 56 Å2
Dissociation energy (ΔGdiss): -3.79 kcal/mol
Dissociation entropy (TΔSdiss): 2.76 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-180096
Assembly 2
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Assembly Name: Endoplasmic reticulum aminopeptidase 2
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Multimeric state: monomeric
Accessible surface area: 35658.02 Å2
Buried surface area: 284.91 Å2
Dissociation area: 0 Å2
Dissociation energy (ΔGdiss): 0 kcal/mol
Dissociation entropy (TΔSdiss): 0 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-180096

Macromolecules

Endoplasmic reticulum aminopeptidase 2
Chains: A, B
Length: 967 amino acids
Theoretical weight: 111.56 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q6P179 (Residues: 1-960; Coverage: 100%)
Gene names: ERAP2, LRAP
Pfam:
InterPro:
Endoplasmic reticulum aminopeptidase 2 in PDB entry 7sh0, assembly 1, front view.
Endoplasmic reticulum aminopeptidase 2 in PDB entry 7sh0, assembly 1, side view.
Endoplasmic reticulum aminopeptidase 2 in PDB entry 7sh0, assembly 1, top view.
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