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Crystal structure of Voltage gated potassium ion channel, Kv 1.2 chimera-3m

X-ray diffraction
3.32Å resolution
PDB entry 7sit coloured by chain, front view.
PDB entry 7sit coloured by chain, side view.
PDB entry 7sit coloured by chain, top view.
Source organism: Rattus norvegicus
Assembly composition:
hetero octamer (preferred)
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Potassium voltage-gated channel subfamily A member 2 and Voltage-gated potassium channel subunit beta-2
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Multimeric state: hetero octamer
Accessible surface area: 110480.23 Å2
Buried surface area: 35741.05 Å2
Dissociation area: 255.83 Å2
Dissociation energy (ΔGdiss): -3.01 kcal/mol
Dissociation entropy (TΔSdiss): 2.33 kcal/mol
Symmetry number: 4
PDBe Complex ID: PDB-CPX-158618
Assembly 2
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Assembly Name: Potassium voltage-gated channel subfamily A member 2 and Voltage-gated potassium channel subunit beta-2
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Multimeric state: hetero octamer
Accessible surface area: 109847.67 Å2
Buried surface area: 35617.21 Å2
Dissociation area: 196.56 Å2
Dissociation energy (ΔGdiss): -1.93 kcal/mol
Dissociation entropy (TΔSdiss): 1.66 kcal/mol
Symmetry number: 4
PDBe Complex ID: PDB-CPX-158618

Macromolecules

Voltage-gated potassium channel subunit beta-2
Chains: A, C
Length: 333 amino acids
Theoretical weight: 37.35 KDa
Source organism: Rattus norvegicus
Expression system: Komagataella pastoris
UniProt:
  • Canonical: P62483 (Residues: 35-367; Coverage: 91%)
Gene names: Ckbeta2, Kcnab2, Kcnb3
Pfam: Aldo/keto reductase family
InterPro:
Voltage-gated potassium channel subunit beta-2 in PDB entry 7sit, assembly 1, front view.
Voltage-gated potassium channel subunit beta-2 in PDB entry 7sit, assembly 1, side view.
Voltage-gated potassium channel subunit beta-2 in PDB entry 7sit, assembly 1, top view.
PDBe-KB: UniProt Coverage View: P62483  
133350100150200250300
 
100200300
UniProt
P62483
Chains
Domains
Secondary structure
Ligand binding sites
Interaction interfaces
Sequence conservation
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Potassium voltage-gated channel subfamily A member 2
Chains: B, D
Length: 514 amino acids
Theoretical weight: 58.82 KDa
Source organism: Rattus norvegicus
Expression system: Komagataella pastoris
UniProt:
  • Canonical: P63142 (Residues: 1-499; Coverage: 99%)
Gene name: Kcna2
Pfam:
InterPro:
Potassium voltage-gated channel subfamily A member 2 in PDB entry 7sit, assembly 1, front view.
Potassium voltage-gated channel subfamily A member 2 in PDB entry 7sit, assembly 1, side view.
Potassium voltage-gated channel subfamily A member 2 in PDB entry 7sit, assembly 1, top view.
PDBe-KB: UniProt Coverage View: P63142  
151450100150200250300350400450500
 
200400
UniProt
P63142
Chains
Domains
Secondary structure
Flexibility predictions
Ligand binding sites
Interaction interfaces
Molecule details ›

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