› 7sk2

Electron Microscopy
3.82Å resolution

Human wildtype GABA reuptake transporter 1 in complex with tiagabine, inward-open conformation

Released:
DOI: 10.2210/pdb7sk2/pdb
PDB entry 7sk2 coloured by chain, front view.
PDB entry 7sk2 coloured by chain, side view.
PDB entry 7sk2 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural basis of GABA reuptake inhibition.
Motiwala Z, Aduri NG, Shaye H, Han GW, Lam JH, Katritch V, Cherezov V, Gati C
Nature 606 820-826 (2022)
PMID: 35676483
Related structures: EMD-25170

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-151757 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Sodium- and chloride-dependent GABA transporter 1 Chain: A
Molecule details ›
Chain: A
Length: 578 amino acids
Theoretical weight: 64.89 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P30531 (Residues: 1-578; Coverage: 97%)
Gene names: GABATR, GABT1, GAT1, SLC6A1
Sequence domains: Sodium:neurotransmitter symporter family

Ligands and Environments

1 bound ligand:
Ligand TGI 1 x TGI
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.82Å
Relevant EMDB volumes: EMD-25170
Expression system: Spodoptera frugiperda

Quick links

Citations

4 review citations

Exploring neurotransmitters and their receptors for breast cancer prevention and treatment.
Li et al. (2023)
3 more

5 mentions without citation

A comparative review on the well-studied GAT1 and the understudied BGT-1 in the brain.
Bhatt et al. (2023)
4 more