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Human wildtype GABA reuptake transporter 1 in complex with tiagabine, inward-open conformation

Electron Microscopy
3.82Å resolution
PDB entry 7sk2 coloured by chain, front view.
PDB entry 7sk2 coloured by chain, side view.
PDB entry 7sk2 coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Sodium- and chloride-dependent GABA transporter 1
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Multimeric state: monomeric
PDBe Complex ID: PDB-CPX-151757

Macromolecules

Sodium- and chloride-dependent GABA transporter 1
Chain: A
Length: 578 amino acids
Theoretical weight: 64.89 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P30531 (Residues: 1-578; Coverage: 97%)
Gene names: GABATR, GABT1, GAT1, SLC6A1
Pfam: Sodium:neurotransmitter symporter family
InterPro:
Sodium- and chloride-dependent GABA transporter 1 in PDB entry 7sk2, assembly 1, front view.
Sodium- and chloride-dependent GABA transporter 1 in PDB entry 7sk2, assembly 1, side view.
Sodium- and chloride-dependent GABA transporter 1 in PDB entry 7sk2, assembly 1, top view.
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