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Cryo-EM structure of ACKR3 in complex with CXCL12 and an intracellular Fab

Electron Microscopy
4Å resolution
PDB entry 7sk5 coloured by chain, front view.
PDB entry 7sk5 coloured by chain, side view.
PDB entry 7sk5 coloured by chain, top view.
Source organisms:
Assembly composition:
hetero pentamer (preferred)
Entry contents: 5 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Multimeric state: hetero pentamer
Accessible surface area: 42982.87 Å2
Buried surface area: 14957.74 Å2
Dissociation area: 625.02 Å2
Dissociation energy (ΔGdiss): -5.43 kcal/mol
Dissociation entropy (TΔSdiss): 12.09 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-225548

Macromolecules

Atypical chemokine receptor 3
Chain: A
Length: 393 amino acids
Theoretical weight: 45.2 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
Atypical chemokine receptor 3 in PDB entry 7sk5, assembly 1, front view.
Atypical chemokine receptor 3 in PDB entry 7sk5, assembly 1, side view.
Atypical chemokine receptor 3 in PDB entry 7sk5, assembly 1, top view.
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CID24 Fab heavy chain
Chain: F
Length: 238 amino acids
Theoretical weight: 25.38 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli 'BL21-Gold(DE3)pLysS AG'
CID24 Fab heavy chain in PDB entry 7sk5, assembly 1, front view.
CID24 Fab heavy chain in PDB entry 7sk5, assembly 1, side view.
CID24 Fab heavy chain in PDB entry 7sk5, assembly 1, top view.
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Stromal cell-derived factor 1
Chain: B
Length: 68 amino acids
Theoretical weight: 7.98 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli 'BL21-Gold(DE3)pLysS AG'
Stromal cell-derived factor 1 in PDB entry 7sk5, assembly 1, front view.
Stromal cell-derived factor 1 in PDB entry 7sk5, assembly 1, side view.
Stromal cell-derived factor 1 in PDB entry 7sk5, assembly 1, top view.
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CID24 Fab light chain
Chain: E
Length: 215 amino acids
Theoretical weight: 23.47 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli 'BL21-Gold(DE3)pLysS AG'
CID24 Fab light chain in PDB entry 7sk5, assembly 1, front view.
CID24 Fab light chain in PDB entry 7sk5, assembly 1, side view.
CID24 Fab light chain in PDB entry 7sk5, assembly 1, top view.
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Anti-Fab nanobody
Chain: K
Length: 123 amino acids
Theoretical weight: 13.39 KDa
Source organism: Lama glama
Expression system: Escherichia coli 'BL21-Gold(DE3)pLysS AG'
Anti-Fab nanobody in PDB entry 7sk5, assembly 1, front view.
Anti-Fab nanobody in PDB entry 7sk5, assembly 1, side view.
Anti-Fab nanobody in PDB entry 7sk5, assembly 1, top view.
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