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Crystallization of feline coronavirus Mpro with GC376 reveals mechanism of inhibition

X-ray diffraction
2.05Å resolution
PDB entry 7sna coloured by chain, front view.
PDB entry 7sna coloured by chain, side view.
PDB entry 7sna coloured by chain, top view.
Source organism: Feline coronavirus
Assembly composition:
homo dimer (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Non-structural protein 3
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Multimeric state: homo dimer
Accessible surface area: 25230.58 Å2
Buried surface area: 2486.04 Å2
Dissociation area: 1,243.02 Å2
Dissociation energy (ΔGdiss): 9.71 kcal/mol
Dissociation entropy (TΔSdiss): 13.93 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-189164

Macromolecules

3C-like proteinase
Chains: A, B
Length: 302 amino acids
Theoretical weight: 33.14 KDa
Source organism: Feline coronavirus
Expression system: Escherichia coli
UniProt:
  • Canonical: Q98VG9 (Residues: 2904-3205; Coverage: 5%)
Gene names: 1a-1b, rep
Pfam: Coronavirus endopeptidase C30
InterPro:
3C-like proteinase in PDB entry 7sna, assembly 1, front view.
3C-like proteinase in PDB entry 7sna, assembly 1, side view.
3C-like proteinase in PDB entry 7sna, assembly 1, top view.
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