PDB 7suj biological assemblies and structure analysis ‹ Protein Data Bank in Europe (PDBe)

Assemblies

Assembly 1 (preferred)

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Assembly Name: Serine/threonine-protein kinase Chk1
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Multimeric state: monomeric

Accessible surface area: 12746.68 Å²

Buried surface area: 0.0 Å²

Dissociation area: 0 Å²

Dissociation energy (ΔG^diss): 0 kcal/mol

Dissociation entropy (TΔS^diss): 0 kcal/mol

Symmetry number: 1

PDBe Complex ID: PDB-CPX-127093

$Monomeric assembly 1 of PDB entry 7suj coloured by chemically distinct molecules, front view. This structure contains: <ul class='image_legend_ul'><li class='image_legend_li'>1 copy of Serine/threonine-protein kinase Chk1;</li> <li class='image_legend_li'>1 copy of (3R,4R)-4-{4-[6-chloro-2-({1-[(1R)-2,2-difluorocyclopropyl]-5-methyl-1H-pyrazol-4-yl}amino)quinazolin-7-yl]piperidin-1-yl}-4-methyloxolan-3-ol;</li> <li class='image_legend_li'>1 copy of water.</li></ul>}$

$Monomeric assembly 1 of PDB entry 7suj coloured by chemically distinct molecules, side view. This structure contains: <ul class='image_legend_ul'><li class='image_legend_li'>1 copy of Serine/threonine-protein kinase Chk1;</li> <li class='image_legend_li'>1 copy of (3R,4R)-4-{4-[6-chloro-2-({1-[(1R)-2,2-difluorocyclopropyl]-5-methyl-1H-pyrazol-4-yl}amino)quinazolin-7-yl]piperidin-1-yl}-4-methyloxolan-3-ol;</li> <li class='image_legend_li'>1 copy of water.</li></ul>}$

$Monomeric assembly 1 of PDB entry 7suj coloured by chemically distinct molecules, top view. This structure contains: <ul class='image_legend_ul'><li class='image_legend_li'>1 copy of Serine/threonine-protein kinase Chk1;</li> <li class='image_legend_li'>1 copy of (3R,4R)-4-{4-[6-chloro-2-({1-[(1R)-2,2-difluorocyclopropyl]-5-methyl-1H-pyrazol-4-yl}amino)quinazolin-7-yl]piperidin-1-yl}-4-methyloxolan-3-ol;</li> <li class='image_legend_li'>1 copy of water.</li></ul>}$

Assembly 2

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Assembly Name: Serine/threonine-protein kinase Chk1
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Multimeric state: monomeric

Accessible surface area: 12825.61 Å²

Buried surface area: 0.0 Å²

Dissociation area: 0 Å²

Dissociation energy (ΔG^diss): 0 kcal/mol

Dissociation entropy (TΔS^diss): 0 kcal/mol

Symmetry number: 1

PDBe Complex ID: PDB-CPX-127093

$Monomeric assembly 2 of PDB entry 7suj coloured by chemically distinct molecules, front view. This structure contains: <ul class='image_legend_ul'><li class='image_legend_li'>1 copy of Serine/threonine-protein kinase Chk1;</li> <li class='image_legend_li'>1 copy of (3R,4R)-4-{4-[6-chloro-2-({1-[(1R)-2,2-difluorocyclopropyl]-5-methyl-1H-pyrazol-4-yl}amino)quinazolin-7-yl]piperidin-1-yl}-4-methyloxolan-3-ol;</li> <li class='image_legend_li'>1 copy of water.</li></ul>}$

$Monomeric assembly 2 of PDB entry 7suj coloured by chemically distinct molecules, side view. This structure contains: <ul class='image_legend_ul'><li class='image_legend_li'>1 copy of Serine/threonine-protein kinase Chk1;</li> <li class='image_legend_li'>1 copy of (3R,4R)-4-{4-[6-chloro-2-({1-[(1R)-2,2-difluorocyclopropyl]-5-methyl-1H-pyrazol-4-yl}amino)quinazolin-7-yl]piperidin-1-yl}-4-methyloxolan-3-ol;</li> <li class='image_legend_li'>1 copy of water.</li></ul>}$

$Monomeric assembly 2 of PDB entry 7suj coloured by chemically distinct molecules, top view. This structure contains: <ul class='image_legend_ul'><li class='image_legend_li'>1 copy of Serine/threonine-protein kinase Chk1;</li> <li class='image_legend_li'>1 copy of (3R,4R)-4-{4-[6-chloro-2-({1-[(1R)-2,2-difluorocyclopropyl]-5-methyl-1H-pyrazol-4-yl}amino)quinazolin-7-yl]piperidin-1-yl}-4-methyloxolan-3-ol;</li> <li class='image_legend_li'>1 copy of water.</li></ul>}$

Macromolecules

Serine/threonine-protein kinase Chk1

Chains: A, B
Length: 297 amino acids
Theoretical weight: 34.09 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:

Canonical: O14757 (Residues: 1-289; Coverage: 61%)
Best match: O14757-2 (Residues: 3-195)

Gene names: CHEK1, CHK1
Pfam: Protein kinase domain
InterPro:

Protein kinase-like domain superfamily
Checkpoint kinase 1, catalytic domain
Protein kinase domain
Protein kinase, ATP binding site
Serine/threonine-protein kinase, active site

Serine/threonine-protein kinase Chk1 in PDB entry 7suj, assembly 1, front view.

Serine/threonine-protein kinase Chk1 in PDB entry 7suj, assembly 1, side view.

Serine/threonine-protein kinase Chk1 in PDB entry 7suj, assembly 1, top view.

FASTA Sequence


    >pdb|7suj|A B

MAVPFVEDWDLVQTLGEGAYGEVQLAVNRVTEEAVAVKIVDMKRAVDCPENIKKEICILKMLNHENVIKFYGHRREGNIQYLFMELASGGSLFDRIEPDIGMPEPDAQRFFHQLMAGVVYLHGIGITHRDIKPHNLLLDERDNLKIADYSLATVFRYNNRERLLNKMCGTLPYVAPELLKRREFHAEPVDVWSCGIVLTAMLAGELPWDQPSDSCQEYSDWKEKKTYLNPWKKIDSAPLALLHKILVENPSARITIPDIKKDRWYNKPLKKGAKRPRVTSGGVSESPSGHHHHHHHH

PDBe-KB: UniProt Coverage View: O14757

Molecule details ›

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FASTA (Protein chains A, B)
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Structure Factors
SIFTS XML file with residue-level mappings

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Similar 3D structures (PDBeFold)
Similar sequences

BLAST O14757 (UniProt)

Protein Data Bank in Europe

Structure of CHK1 10-pt. mutant complex with LRRK2 inhibitor 24

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Assemblies

Assembly 1 (preferred)

Assembly 2

Macromolecules

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PDBe › 7suj › Structure analysis

Structure of CHK1 10-pt. mutant complex with LRRK2 inhibitor 24

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Assemblies

Assembly 1 (preferred)

Assembly 2

Macromolecules

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7suj › Structure analysis