› › Structure analysis

The complex of dephosphorylated human cystic fibrosis transmembrane conductance regulator (CFTR) and Lumacaftor (VX-809)

Electron Microscopy
3.9Å resolution
PDB entry 7svr coloured by chain, front view.
PDB entry 7svr coloured by chain, side view.
PDB entry 7svr coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
hetero dimer (preferred)
Entry contents: 2 distinct polypeptide molecules

Quick links

Assemblies

Assembly 1 (preferred)
Download    3D Visualisation
Assembly Name: Cystic fibrosis transmembrane conductance regulator and peptide
hide full assembly name
Multimeric state: hetero dimer
Accessible surface area: 56621.74 Å2
Buried surface area: 1070.61 Å2
Dissociation area: 535.31 Å2
Dissociation energy (ΔGdiss): -3.45 kcal/mol
Dissociation entropy (TΔSdiss): 7.98 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-146649

Macromolecules

Cystic fibrosis transmembrane conductance regulator
Chain: A
Length: 1480 amino acids
Theoretical weight: 168.34 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P13569 (Residues: 1-1480; Coverage: 100%)
Gene names: ABCC7, CFTR
Pfam:
InterPro:
Cystic fibrosis transmembrane conductance regulator in PDB entry 7svr, assembly 1, front view.
Cystic fibrosis transmembrane conductance regulator in PDB entry 7svr, assembly 1, side view.
Cystic fibrosis transmembrane conductance regulator in PDB entry 7svr, assembly 1, top view.
Molecule details ›

Search similar proteins

Cystic fibrosis transmembrane conductance regulator
Chain: B
Length: 19 amino acids
Theoretical weight: 1.64 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
Cystic fibrosis transmembrane conductance regulator in PDB entry 7svr, assembly 1, front view.
Cystic fibrosis transmembrane conductance regulator in PDB entry 7svr, assembly 1, side view.
Cystic fibrosis transmembrane conductance regulator in PDB entry 7svr, assembly 1, top view.
Molecule details ›

Search similar proteins

Quick links