› 7syf

Electron Microscopy
4.2Å resolution

Reconstruction of full-length Prex-1 (PtdIns(3,4,5)P3-dependent Rac Exchanger 1)

Released:
DOI: 10.2210/pdb7syf/pdb
PDB entry 7syf coloured by chain, front view.
PDB entry 7syf coloured by chain, side view.
PDB entry 7syf coloured by chain, top view.
Source organisms:
Primary publication:
Structure of the metastatic factor P-Rex1 reveals a two-layered autoinhibitory mechanism.
Chang YG, Lupton CJ, Bayly-Jones C, Keen AC, D'Andrea L, Lucato CM, Steele JR, Venugopal H, Schittenhelm RB, Whisstock JC, Halls ML, Ellisdon AM
OpenAccess logo Nat Struct Mol Biol (2022)
PMID: 35864164
Related structures: EMD-25524

Function and Biology Details

Reaction catalysed: 
Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-112948 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Endolysin; Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein Chain: A
Molecule details ›
Chain: A
Length: 1690 amino acids
Theoretical weight: 191.46 KDa
Source organisms: Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q8TCU6 (Residues: 41-305, 323-1117, 1119-1659; Coverage: 91%)
  • Canonical: D9IEF7 (Residues: 2-161; Coverage: 98%)
Gene names: KIAA1415, PREX1, T4Tp126, e
Sequence domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 4.2Å
Relevant EMDB volumes: EMD-25524
Expression system: Spodoptera frugiperda

Quick links

Citations

2 citation in other articles

ECL 3.0: a sensitive peptide identification tool for cross-linking mass spectrometry data analysis.
Zhou et al. (2023)
1 more

2 mentions without citation

Structure of the metastatic factor P-Rex1 reveals a two-layered autoinhibitory mechanism.
Chang et al. (2022)
1 more