› 7t0u

X-ray diffraction
1.49Å resolution

Crystal structure of the BCL6 BTB domain in complex with OICR-12387

Released:
DOI: 10.2210/pdb7t0u/pdb
PDB entry 7t0u coloured by chain, front view.
PDB entry 7t0u coloured by chain, side view.
PDB entry 7t0u coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Kuntz DA, Prive GG

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-154263 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
B-cell lymphoma 6 protein Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 127 amino acids
Theoretical weight: 14.56 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P41182 (Residues: 5-129; Coverage: 18%)
Gene names: BCL5, BCL6, LAZ3, ZBTB27, ZNF51
Sequence domains: BTB/POZ domain

Ligands and Environments

5 bound ligands:
Ligand SO4 2 x SO4
Ligand GOL 2 x GOL
Ligand CL 3 x CL
Ligand E3I 4 x E3I
Ligand DMS 1 x DMS
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 17-ID
Spacegroup: P21
Unit cell:
a: 55.484Å b: 72.545Å c: 67.488Å
α: 90° β: 109.15° γ: 90°
R-values:
R R work R free
0.142 0.141 0.18
Expression system: Escherichia coli BL21(DE3)

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