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Crystal structure of the BCL6 BTB domain in complex with OICR-12387

X-ray diffraction
1.49Å resolution
PDB entry 7t0u coloured by chain, front view.
PDB entry 7t0u coloured by chain, side view.
PDB entry 7t0u coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
homo dimer (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1
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Assembly Name: B-cell lymphoma 6 protein
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Multimeric state: homo dimer
Accessible surface area: 12297.18 Å2
Buried surface area: 4983.29 Å2
Dissociation area: 2,197.31 Å2
Dissociation energy (ΔGdiss): 32.78 kcal/mol
Dissociation entropy (TΔSdiss): 12.39 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-154263
Assembly 2 (preferred)
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Assembly Name: B-cell lymphoma 6 protein
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Multimeric state: homo dimer
Accessible surface area: 12717.05 Å2
Buried surface area: 4857.42 Å2
Dissociation area: 2,154.6 Å2
Dissociation energy (ΔGdiss): 22.14 kcal/mol
Dissociation entropy (TΔSdiss): 12.37 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-154263

Macromolecules

B-cell lymphoma 6 protein
Chains: A, B, C, D
Length: 127 amino acids
Theoretical weight: 14.56 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P41182 (Residues: 5-129; Coverage: 18%)
Gene names: BCL5, BCL6, LAZ3, ZBTB27, ZNF51
Pfam: BTB/POZ domain
InterPro:
B-cell lymphoma 6 protein in PDB entry 7t0u, assembly 2, front view.
B-cell lymphoma 6 protein in PDB entry 7t0u, assembly 2, side view.
B-cell lymphoma 6 protein in PDB entry 7t0u, assembly 2, top view.
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