› › Structure analysis

Crystal structure of the 5F TCR in complex with HLA-DP4-Ply

X-ray diffraction
2.8Å resolution
PDB entry 7t2b coloured by chain, front view.
PDB entry 7t2b coloured by chain, side view.
PDB entry 7t2b coloured by chain, top view.
Source organisms:
Assembly composition:
hetero pentamer (preferred)
Entry contents: 5 distinct polypeptide molecules

Quick links

Assemblies

Assembly 1
Download    3D Visualisation
Multimeric state: hetero pentamer
Accessible surface area: 37309.85 Å2
Buried surface area: 15973.51 Å2
Dissociation area: 2,422.85 Å2
Dissociation energy (ΔGdiss): 10.77 kcal/mol
Dissociation entropy (TΔSdiss): 22.69 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-134735
Assembly 2 (preferred)
Download    3D Visualisation
Multimeric state: hetero pentamer
Accessible surface area: 38132.92 Å2
Buried surface area: 15307.17 Å2
Dissociation area: 1,046.19 Å2
Dissociation energy (ΔGdiss): -7.44 kcal/mol
Dissociation entropy (TΔSdiss): 13.87 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-134735
Assembly 3
Download    3D Visualisation
Multimeric state: hetero pentamer
Accessible surface area: 37104.52 Å2
Buried surface area: 15223.63 Å2
Dissociation area: 2,423.12 Å2
Dissociation energy (ΔGdiss): 8.07 kcal/mol
Dissociation entropy (TΔSdiss): 22.55 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-134735
Assembly 4
Download    3D Visualisation
Multimeric state: hetero pentamer
Accessible surface area: 37939.16 Å2
Buried surface area: 15858.12 Å2
Dissociation area: 2,471.98 Å2
Dissociation energy (ΔGdiss): 9.04 kcal/mol
Dissociation entropy (TΔSdiss): 22.73 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-134735

Macromolecules

HLA class II histocompatibility antigen, DP alpha 1 chain
Chains: A, F, K, P
Length: 181 amino acids
Theoretical weight: 20.94 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
  • Canonical: P20036 (Residues: 32-212; Coverage: 78%)
Gene names: HLA-DP1A, HLA-DPA1, HLASB
Pfam:
InterPro:
HLA class II histocompatibility antigen, DP alpha 1 chain in PDB entry 7t2b, assembly 2, front view.
HLA class II histocompatibility antigen, DP alpha 1 chain in PDB entry 7t2b, assembly 2, side view.
HLA class II histocompatibility antigen, DP alpha 1 chain in PDB entry 7t2b, assembly 2, top view.
Molecule details ›

Search similar proteins

HLA class II histocompatibility antigen, DP beta 1 chain
Chains: B, G, L, Q
Length: 190 amino acids
Theoretical weight: 22.07 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
  • Canonical: P04440 (Residues: 30-217; Coverage: 82%)
Gene names: HLA-DP1B, HLA-DPB1
Pfam:
InterPro:
HLA class II histocompatibility antigen, DP beta 1 chain in PDB entry 7t2b, assembly 2, front view.
HLA class II histocompatibility antigen, DP beta 1 chain in PDB entry 7t2b, assembly 2, side view.
HLA class II histocompatibility antigen, DP beta 1 chain in PDB entry 7t2b, assembly 2, top view.
Molecule details ›

Search similar proteins

Pneumolysin
Chains: C, H, M, R
Length: 15 amino acids
Theoretical weight: 1.83 KDa
Source organism: Streptococcus pneumoniae
Expression system: Trichoplusia ni
UniProt:
  • Canonical: Q04IN8 (Residues: 429-441; Coverage: 3%)
Gene names: SPD_1726, ply
Pneumolysin in PDB entry 7t2b, assembly 2, front view.
Pneumolysin in PDB entry 7t2b, assembly 2, side view.
Pneumolysin in PDB entry 7t2b, assembly 2, top view.
Molecule details ›

Search similar proteins

T cell receptor alpha chain constant
Chains: D, I, N, S
Length: 207 amino acids
Theoretical weight: 22.81 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P01848 (Residues: 1-93; Coverage: 66%)
Gene names: TCRA, TRAC
Pfam: Domain of unknown function (DUF1968)
InterPro:
T cell receptor alpha chain constant in PDB entry 7t2b, assembly 2, front view.
T cell receptor alpha chain constant in PDB entry 7t2b, assembly 2, side view.
T cell receptor alpha chain constant in PDB entry 7t2b, assembly 2, top view.
Molecule details ›

Search similar proteins

T cell receptor beta constant 1
Chains: E, J, O, T
Length: 241 amino acids
Theoretical weight: 27.02 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P01850 (Residues: 1-129; Coverage: 73%)
Gene name: TRBC1
Pfam: Immunoglobulin C1-set domain
InterPro:
T cell receptor beta constant 1 in PDB entry 7t2b, assembly 2, front view.
T cell receptor beta constant 1 in PDB entry 7t2b, assembly 2, side view.
T cell receptor beta constant 1 in PDB entry 7t2b, assembly 2, top view.
Molecule details ›

Search similar proteins

Quick links