Assemblies
Assembly Name:
RAG guanosine triphosphatase complex, RAGA-RAGC variant
Multimeric state:
hetero decamer
Accessible surface area:
123259.19 Å2
Buried surface area:
34213.91 Å2
Dissociation area:
1,929.58
Å2
Dissociation energy (ΔGdiss):
13.98
kcal/mol
Dissociation entropy (TΔSdiss):
15.74
kcal/mol
Symmetry number:
1
PDBe Complex ID:
PDB-CPX-128939
Macromolecules
Chain: E
Length: 399 amino acids
Theoretical weight: 44.2 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
Pfam: Gtr1/RagA G protein conserved region
InterPro:
Length: 399 amino acids
Theoretical weight: 44.2 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
- Canonical:
Q9HB90 (Residues: 1-399; Coverage: 100%)
Pfam: Gtr1/RagA G protein conserved region
InterPro:
Chain: B
Length: 380 amino acids
Theoretical weight: 43.71 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
Pfam: Nitrogen permease regulator 2
InterPro: Nitrogen permease regulator 2-like
Length: 380 amino acids
Theoretical weight: 43.71 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
- Canonical:
Q8WTW4 (Residues: 1-380; Coverage: 100%)
Pfam: Nitrogen permease regulator 2
InterPro: Nitrogen permease regulator 2-like
Chain: A
Length: 1603 amino acids
Theoretical weight: 181.39 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
Pfam:
Length: 1603 amino acids
Theoretical weight: 181.39 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
- Canonical:
O75140 (Residues: 1-1603; Coverage: 100%)
Pfam:
- IML1 N-terminal double psi beta barrel domain
- Vacuolar membrane-associated protein Iml1, N-terminal domain
- Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP)
- DEPDC5 protein C-terminal region
Chain: H
Length: 124 amino acids
Theoretical weight: 13.64 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
Pfam: Mitogen-activated protein kinase kinase 1 interacting
InterPro: Ragulator complex protein LAMTOR3
Length: 124 amino acids
Theoretical weight: 13.64 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
- Canonical:
Q9UHA4 (Residues: 1-124; Coverage: 100%)
Pfam: Mitogen-activated protein kinase kinase 1 interacting
InterPro: Ragulator complex protein LAMTOR3
Chain: G
Length: 125 amino acids
Theoretical weight: 13.52 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
Pfam: Roadblock/LC7 domain
InterPro:
Length: 125 amino acids
Theoretical weight: 13.52 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
- Canonical:
Q9Y2Q5 (Residues: 1-125; Coverage: 100%)
Pfam: Roadblock/LC7 domain
InterPro:
Chain: J
Length: 91 amino acids
Theoretical weight: 9.62 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
Pfam: Ragulator complex protein LAMTOR5
InterPro: Ragulator complex protein LAMTOR5
Length: 91 amino acids
Theoretical weight: 9.62 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
- Canonical:
O43504 (Residues: 1-91; Coverage: 100%)
Pfam: Ragulator complex protein LAMTOR5
InterPro: Ragulator complex protein LAMTOR5
Chain: I
Length: 99 amino acids
Theoretical weight: 10.75 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
InterPro: Ragulator complex protein LAMTOR4
Length: 99 amino acids
Theoretical weight: 10.75 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
- Canonical:
Q0VGL1 (Residues: 1-99; Coverage: 100%)
InterPro: Ragulator complex protein LAMTOR4
Chain: F
Length: 161 amino acids
Theoretical weight: 17.76 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
Pfam: Late endosomal/lysosomal adaptor and MAPK and MTOR activator
InterPro: LAMTOR1/MEH1
Length: 161 amino acids
Theoretical weight: 17.76 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
- Canonical:
Q6IAA8 (Residues: 1-161; Coverage: 100%)
Pfam: Late endosomal/lysosomal adaptor and MAPK and MTOR activator
InterPro: LAMTOR1/MEH1
Chain: C
Length: 569 amino acids
Theoretical weight: 63.68 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
Pfam: Nitrogen Permease regulator of amino acid transport activity 3
InterPro: Nitrogen permease regulator 3
Length: 569 amino acids
Theoretical weight: 63.68 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
- Canonical:
Q12980 (Residues: 1-569; Coverage: 100%)
Pfam: Nitrogen Permease regulator of amino acid transport activity 3
InterPro: Nitrogen permease regulator 3
Chain: D
Length: 313 amino acids
Theoretical weight: 36.62 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
Pfam: Gtr1/RagA G protein conserved region
InterPro:
Length: 313 amino acids
Theoretical weight: 36.62 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
- Canonical:
Q7L523 (Residues: 1-313; Coverage: 100%)
Pfam: Gtr1/RagA G protein conserved region
InterPro: