› › Structure analysis

GATOR1-RAG-RAGULATOR - GAP Complex

Electron Microscopy
3.9Å resolution
PDB entry 7t3b coloured by chain, front view.
PDB entry 7t3b coloured by chain, side view.
PDB entry 7t3b coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
hetero decamer (preferred)
Entry contents: 10 distinct polypeptide molecules

Quick links

Assemblies

Assembly 1 (preferred)
Download    3D Visualisation
Assembly Name: RAG guanosine triphosphatase complex, RAGA-RAGC variant
hide full assembly name
Multimeric state: hetero decamer
Accessible surface area: 123259.19 Å2
Buried surface area: 34213.91 Å2
Dissociation area: 1,929.58 Å2
Dissociation energy (ΔGdiss): 13.98 kcal/mol
Dissociation entropy (TΔSdiss): 15.74 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-128939

Macromolecules

Ras-related GTP-binding protein C
Chain: E
Length: 399 amino acids
Theoretical weight: 44.2 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q9HB90 (Residues: 1-399; Coverage: 100%)
Gene name: RRAGC
Pfam: Gtr1/RagA G protein conserved region
InterPro:
Ras-related GTP-binding protein C in PDB entry 7t3b, assembly 1, front view.
Ras-related GTP-binding protein C in PDB entry 7t3b, assembly 1, side view.
Ras-related GTP-binding protein C in PDB entry 7t3b, assembly 1, top view.
Molecule details ›

Search similar proteins

GATOR1 complex protein NPRL2
Chain: B
Length: 380 amino acids
Theoretical weight: 43.71 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q8WTW4 (Residues: 1-380; Coverage: 100%)
Gene names: NPRL2, TUSC4
Pfam: Nitrogen permease regulator 2
InterPro: Nitrogen permease regulator 2-like
GATOR1 complex protein NPRL2 in PDB entry 7t3b, assembly 1, front view.
GATOR1 complex protein NPRL2 in PDB entry 7t3b, assembly 1, side view.
GATOR1 complex protein NPRL2 in PDB entry 7t3b, assembly 1, top view.
Molecule details ›

Search similar proteins

GATOR1 complex protein DEPDC5
Chain: A
Length: 1603 amino acids
Theoretical weight: 181.39 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: O75140 (Residues: 1-1603; Coverage: 100%)
Gene names: DEPDC5, KIAA0645
Pfam:
InterPro:
GATOR1 complex protein DEPDC5 in PDB entry 7t3b, assembly 1, front view.
GATOR1 complex protein DEPDC5 in PDB entry 7t3b, assembly 1, side view.
GATOR1 complex protein DEPDC5 in PDB entry 7t3b, assembly 1, top view.
Molecule details ›

Search similar proteins

Ragulator complex protein LAMTOR3
Chain: H
Length: 124 amino acids
Theoretical weight: 13.64 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q9UHA4 (Residues: 1-124; Coverage: 100%)
Gene names: LAMTOR3, MAP2K1IP1, MAPKSP1, PRO2783
Pfam: Mitogen-activated protein kinase kinase 1 interacting
InterPro: Ragulator complex protein LAMTOR3
Ragulator complex protein LAMTOR3 in PDB entry 7t3b, assembly 1, front view.
Ragulator complex protein LAMTOR3 in PDB entry 7t3b, assembly 1, side view.
Ragulator complex protein LAMTOR3 in PDB entry 7t3b, assembly 1, top view.
Molecule details ›

Search similar proteins

Ragulator complex protein LAMTOR2
Chain: G
Length: 125 amino acids
Theoretical weight: 13.52 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q9Y2Q5 (Residues: 1-125; Coverage: 100%)
Gene names: HSPC003, LAMTOR2, MAPBPIP, ROBLD3
Pfam: Roadblock/LC7 domain
InterPro:
Ragulator complex protein LAMTOR2 in PDB entry 7t3b, assembly 1, front view.
Ragulator complex protein LAMTOR2 in PDB entry 7t3b, assembly 1, side view.
Ragulator complex protein LAMTOR2 in PDB entry 7t3b, assembly 1, top view.
Molecule details ›

Search similar proteins

Ragulator complex protein LAMTOR5
Chain: J
Length: 91 amino acids
Theoretical weight: 9.62 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: O43504 (Residues: 1-91; Coverage: 100%)
Gene names: HBXIP, LAMTOR5, XIP
Pfam: Ragulator complex protein LAMTOR5
InterPro: Ragulator complex protein LAMTOR5
Ragulator complex protein LAMTOR5 in PDB entry 7t3b, assembly 1, front view.
Ragulator complex protein LAMTOR5 in PDB entry 7t3b, assembly 1, side view.
Ragulator complex protein LAMTOR5 in PDB entry 7t3b, assembly 1, top view.
Molecule details ›

Search similar proteins

Ragulator complex protein LAMTOR4
Chain: I
Length: 99 amino acids
Theoretical weight: 10.75 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q0VGL1 (Residues: 1-99; Coverage: 100%)
Gene names: C7orf59, LAMTOR4
InterPro: Ragulator complex protein LAMTOR4
Ragulator complex protein LAMTOR4 in PDB entry 7t3b, assembly 1, front view.
Ragulator complex protein LAMTOR4 in PDB entry 7t3b, assembly 1, side view.
Ragulator complex protein LAMTOR4 in PDB entry 7t3b, assembly 1, top view.
Molecule details ›

Search similar proteins

Ragulator complex protein LAMTOR1
Chain: F
Length: 161 amino acids
Theoretical weight: 17.76 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q6IAA8 (Residues: 1-161; Coverage: 100%)
Gene names: C11orf59, LAMTOR1, PDRO, PP7157
Pfam: Late endosomal/lysosomal adaptor and MAPK and MTOR activator
InterPro: LAMTOR1/MEH1
Ragulator complex protein LAMTOR1 in PDB entry 7t3b, assembly 1, front view.
Ragulator complex protein LAMTOR1 in PDB entry 7t3b, assembly 1, side view.
Ragulator complex protein LAMTOR1 in PDB entry 7t3b, assembly 1, top view.
Molecule details ›

Search similar proteins

GATOR1 complex protein NPRL3
Chain: C
Length: 569 amino acids
Theoretical weight: 63.68 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q12980 (Residues: 1-569; Coverage: 100%)
Gene names: C16orf35, CGTHBA, MARE, NPRL3
Pfam: Nitrogen Permease regulator of amino acid transport activity 3
InterPro: Nitrogen permease regulator 3
GATOR1 complex protein NPRL3 in PDB entry 7t3b, assembly 1, front view.
GATOR1 complex protein NPRL3 in PDB entry 7t3b, assembly 1, side view.
GATOR1 complex protein NPRL3 in PDB entry 7t3b, assembly 1, top view.
Molecule details ›

Search similar proteins

Ras-related GTP-binding protein A
Chain: D
Length: 313 amino acids
Theoretical weight: 36.62 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q7L523 (Residues: 1-313; Coverage: 100%)
Gene name: RRAGA
Pfam: Gtr1/RagA G protein conserved region
InterPro:
Ras-related GTP-binding protein A in PDB entry 7t3b, assembly 1, front view.
Ras-related GTP-binding protein A in PDB entry 7t3b, assembly 1, side view.
Ras-related GTP-binding protein A in PDB entry 7t3b, assembly 1, top view.
Molecule details ›

Search similar proteins

Quick links