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The hexagonal organization of Munc13-1 C1-C2B-MUN-C2C domains between lipid bilayers

Electron Microscopy
10Å resolution
PDB entry 7t7c coloured by chain, front view.
PDB entry 7t7c coloured by chain, side view.
PDB entry 7t7c coloured by chain, top view.
Source organisms:
Assembly composition:
homo dodecamer (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Protein unc-13 homolog A, Unc-13 homolog A
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Multimeric state: homo dodecamer
Accessible surface area: 570264.86 Å2
Buried surface area: 18722.41 Å2
Dissociation area: 9,361.2 Å2
Dissociation energy (ΔGdiss): -172.67 kcal/mol
Dissociation entropy (TΔSdiss): 202.04 kcal/mol
Symmetry number: 6
PDBe Complex ID: PDB-CPX-246202

Macromolecules

Protein unc-13 homolog A; Unc-13 homolog A
Chains: A, B, C, D, E, F, G, H, I, J, K, L
Length: 1154 amino acids
Theoretical weight: 130.9 KDa
Source organisms: Expression system: Homo sapiens
UniProt:
  • Canonical: Q4KUS2 (Residues: 525-656, 1448-1712; Coverage: 23%)
  • Canonical: A0A822AJ50 (Residues: 657-1403; Coverage: 43%)
    • nullnull
Gene names: RIMITATOR_LOCUS6943369, Unc13a
Pfam:
InterPro:
Protein unc-13 homolog A in PDB entry 7t7c, assembly 1, front view.
Protein unc-13 homolog A in PDB entry 7t7c, assembly 1, side view.
Protein unc-13 homolog A in PDB entry 7t7c, assembly 1, top view.
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