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M22 Agonist Autoantibody bound to Human Thyrotropin receptor in complex with miniGs399 (composite structure)

Source organism: Homo sapiens
Biochemical function: protein binding
Biological process: G protein-coupled receptor signaling pathway
Cellular component: membrane

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GO terms

Biochemical function:
Biological process:
Cellular component:

Sequence families

Pfam Protein families (Pfam)
PF00400
Domain description: WD domain, G-beta repeat
Occurring in:
  1. Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
The deposited structure of PDB entry 7t9n contains 7 copies of Pfam domain PF00400 (WD domain, G-beta repeat) in Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1. Showing 7 copies in chain F [auth Y].

PF13306
Domain description: BspA type Leucine rich repeat region (6 copies)
Occurring in:
  1. Thyrotropin receptor
The deposited structure of PDB entry 7t9n contains 2 copies of Pfam domain PF13306 (BspA type Leucine rich repeat region (6 copies)) in Thyrotropin receptor. Showing 2 copies in chain D [auth R].

PF00631
Domain description: GGL domain
Occurring in:
  1. Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2
The deposited structure of PDB entry 7t9n contains 1 copy of Pfam domain PF00631 (GGL domain) in Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2. Showing 1 copy in chain G [auth Z].

PF00503
Domain description: G-protein alpha subunit
Occurring in:
  1. Guanine nucleotide-binding protein G(s) subunit alpha isoforms short
The deposited structure of PDB entry 7t9n contains 1 copy of Pfam domain PF00503 (G-protein alpha subunit) in Guanine nucleotide-binding protein G(s) subunit alpha isoforms short. Showing 1 copy in chain E [auth X].

PF00001
Domain description: 7 transmembrane receptor (rhodopsin family)
Occurring in:
  1. Thyrotropin receptor
The deposited structure of PDB entry 7t9n contains 1 copy of Pfam domain PF00001 (7 transmembrane receptor (rhodopsin family)) in Thyrotropin receptor. Showing 1 copy in chain D [auth R].

InterPro InterPro annotations
IPR001680
Domain description: WD40 repeat
Occurring in:
  1. Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
IPR000276
Domain description: G protein-coupled receptor, rhodopsin-like
Occurring in:
  1. Thyrotropin receptor
IPR002274
Domain description: Thyrotropin receptor
Occurring in:
  1. Thyrotropin receptor
IPR002131
Domain description: Glycoprotein hormone receptor family
Occurring in:
  1. Thyrotropin receptor
IPR013106
Domain description: Immunoglobulin V-set domain
Occurring in:
  1. M22 Fab heavy chain
  2. M22 Fab light chain
  3. Nanobody 35
IPR001019
Domain description: Guanine nucleotide binding protein (G-protein), alpha subunit
Occurring in:
  1. Guanine nucleotide-binding protein G(s) subunit alpha isoforms short
IPR003599
Domain description: Immunoglobulin subtype
Occurring in:
  1. M22 Fab heavy chain
  2. M22 Fab light chain
  3. Nanobody 35
IPR036179
Domain description: Immunoglobulin-like domain superfamily
Occurring in:
  1. M22 Fab heavy chain
  2. M22 Fab light chain
  3. Nanobody 35
IPR013783
Domain description: Immunoglobulin-like fold
Occurring in:
  1. M22 Fab heavy chain
  2. M22 Fab light chain
  3. Nanobody 35
IPR007110
Domain description: Immunoglobulin-like domain
Occurring in:
  1. M22 Fab heavy chain
  2. M22 Fab light chain
  3. Nanobody 35
IPR015898
Domain description: G-protein gamma-like domain
Occurring in:
  1. Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2
IPR001770
Domain description: G-protein, gamma subunit
Occurring in:
  1. Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2
IPR001632
Domain description: G-protein, beta subunit
Occurring in:
  1. Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
IPR003597
Domain description: Immunoglobulin C1-set
Occurring in:
  1. M22 Fab heavy chain
  2. M22 Fab light chain
IPR020472
Domain description: G-protein beta WD-40 repeat
Occurring in:
  1. Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
IPR000367
Domain description: G-protein alpha subunit, group S
Occurring in:
  1. Guanine nucleotide-binding protein G(s) subunit alpha isoforms short
IPR036284
Domain description: G-protein gamma-like domain superfamily
Occurring in:
  1. Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2
IPR027417
Domain description: P-loop containing nucleoside triphosphate hydrolase
Occurring in:
  1. Guanine nucleotide-binding protein G(s) subunit alpha isoforms short
IPR026906
Domain description: BspA-type LRR region
Occurring in:
  1. Thyrotropin receptor
IPR003006
Domain description: Immunoglobulin/major histocompatibility complex, conserved site
Occurring in:
  1. M22 Fab heavy chain
  2. M22 Fab light chain
IPR019775
Domain description: WD40 repeat, conserved site
Occurring in:
  1. Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
IPR036322
Domain description: WD40-repeat-containing domain superfamily
Occurring in:
  1. Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
IPR016346
Domain description: Guanine nucleotide-binding protein, beta subunit
Occurring in:
  1. Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
IPR015943
Domain description: WD40/YVTN repeat-like-containing domain superfamily
Occurring in:
  1. Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
IPR005225
Domain description: Small GTP-binding protein domain
Occurring in:
  1. Guanine nucleotide-binding protein G(s) subunit alpha isoforms short
IPR017452
Domain description: GPCR, rhodopsin-like, 7TM
Occurring in:
  1. Thyrotropin receptor
IPR032675
Domain description: Leucine-rich repeat domain superfamily
Occurring in:
  1. Thyrotropin receptor

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