› 7thy

Electron Microscopy
5.2Å resolution

Structure of Leucine Rich Repeat Kinase 2's ROC domain interacting with the microtubule facing the minus end

Released:
DOI: 10.2210/pdb7thy/pdb
PDB entry 7thy coloured by chain, ensemble of 5 models, front view.
PDB entry 7thy coloured by chain, ensemble of 5 models, side view.
PDB entry 7thy coloured by chain, ensemble of 5 models, top view.
Source organism: Homo sapiens
Primary publication:
Structural basis for Parkinson's disease-linked LRRK2's binding to microtubules.
Snead DM, Matyszewski M, Dickey AM, Lin YX, Leschziner AE, Reck-Peterson SL
OpenAccess logo Nat Struct Mol Biol 29 1196-1207 (2022)
PMID: 36510024
Related structures: EMD-25906

Function and Biology Details

Reaction catalysed: 
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-177793 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Leucine-rich repeat serine/threonine-protein kinase 2 Chain: A
Molecule details ›
Chain: A
Length: 194 amino acids
Theoretical weight: 22.19 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q5S007 (Residues: 1332-1525; Coverage: 8%)
Gene names: LRRK2, PARK8
Sequence domains: Ras of Complex, Roc, domain of DAPkinase

Ligands and Environments

1 bound ligand:
Ligand GDP 1 x GDP
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 5.2Å
Relevant EMDB volumes: EMD-25906
Expression system: Spodoptera frugiperda

Quick links

Citations

3 review citations

Tubulin Post-Translational Modifications: The Elusive Roles of Acetylation.
Carmona et al. (2023)
2 more

2 mentions without citation

An Update on the Interplay between LRRK2, Rab GTPases and Parkinson's Disease.
Komori et al. (2023)
1 more